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The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
Moon EJ, Mello SS, Li CG, Chi JT, Thakkar K, Kirkland JG, Lagory EL, Lee IJ, Diep AN, Miao Y, Rafat M, Vilalta M, Castellini L, Krieg AJ, Graves EE, Attardi LD, Giaccia AJ. Moon EJ, et al. Among authors: thakkar k. Nat Commun. 2021 Jul 14;12(1):4308. doi: 10.1038/s41467-021-24631-6. Nat Commun. 2021. PMID: 34262028 Free PMC article.
The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB. Xiao Y, et al. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817424 Free PMC article.
Regulation of gene expression in human cancers by TRIM24.
Appikonda S, Thakkar KN, Barton MC. Appikonda S, et al. Drug Discov Today Technol. 2016 Mar;19:57-63. doi: 10.1016/j.ddtec.2016.05.001. Epub 2016 Aug 10. Drug Discov Today Technol. 2016. PMID: 27769359 Review.
Tissue-specific metabolism and TRIM24.
Thakkar KN, Stratton SA, Craig Barton M. Thakkar KN, et al. Aging (Albany NY). 2015 Oct;7(10):736-7. doi: 10.18632/aging.100822. Aging (Albany NY). 2015. PMID: 26454661 Free PMC article. No abstract available.
TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.
Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. Pathiraja TN, et al. Among authors: thakkar kn. Oncogene. 2015 May 28;34(22):2836-45. doi: 10.1038/onc.2014.220. Epub 2014 Jul 28. Oncogene. 2015. PMID: 25065590 Free PMC article.
243 results