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Page 1
Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment.
Moraes VT, Caires FJ, da Silva-Neto PV, Mendonça JN, Fraga-Silva TFC, Fontanezi BB, Marcato PD, Deperon Bonato VL, Sorgi CA, Beraldo Moraes LA, Clososki GC. Moraes VT, et al. Among authors: fraga silva tfc. RSC Adv. 2024 Feb 21;14(10):6532-6541. doi: 10.1039/d3ra08173g. eCollection 2024 Feb 21. RSC Adv. 2024. PMID: 38390504 Free PMC article.
Alpha 1-acid glycoprotein is upregulated in severe COVID-19 patients and decreases neutrophil NETs in SARS-CoV-2 infection.
Mestriner F, Francisco DF, Campos LCB, Couto AES, Fraga-Silva TFC, Flora Dugaich V, D Avila-Mesquita C, Zukowski Kovacs H, Vasconcelos JL, Milani ER, Santos Guedes de Sá K, Martins R, Jordani MC, Corsi CAC, Barbosa JM, Vasconcelos T, Gonçalves Menegueti M, Neto J, da Costa RM, Evora PRB, Arruda E, Tostes R, Polonis K, Bonato VLD, Auxiliadora-Martins M, Ribeiro MS, Becari C. Mestriner F, et al. Among authors: fraga silva tfc. Cytokine. 2024 Apr;176:156503. doi: 10.1016/j.cyto.2024.156503. Epub 2024 Jan 31. Cytokine. 2024. PMID: 38301358
Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19.
Fraga-Silva TFC, Cipriano UG, Fumagalli MJ, Correa GF, Fuzo CA, Dos-Santos D, Mestriner FLAC, Becari C, Teixeira-Carvalho A, Coelho-Dos-Reis J, Menegueti MG, Figueiredo LTM, Cunha LD, Martins-Filho OA, Dias-Baruffi M, Auxiliadora-Martins M, Tostes RC, Bonato VLD. Fraga-Silva TFC, et al. iScience. 2023 Oct 31;26(12):108366. doi: 10.1016/j.isci.2023.108366. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047070 Free PMC article.
Divergent androgenic modulation of SARS-CoV-2 infection cooperates with dysregulated immune response to dictate worse COVID-19 outcomes in men.
Duarte-Silva M, Oliveira CNS, Fuzo C, Silva-Neto PV, Toro DM, Pimentel VE, Pérez MM, Fraga-Silva TFC, Carvalho JCS, Neto FMS, Júnior RBM, Arruda E, Vilar FC, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, Gaspar GG, Rocha JJR, Feres O, Fernandes APM, Maruyama SR, Russo EMS, Bonato VLD, Santos IKFM, Sorgi CA, Dias-Baruffi M, Faccioli LH, Cardoso CRB; ImmunoCOVID Brazilian Research Consortium. Duarte-Silva M, et al. Among authors: fraga silva tfc. Brain Behav Immun. 2023 Nov;114:275-286. doi: 10.1016/j.bbi.2023.08.026. Epub 2023 Aug 28. Brain Behav Immun. 2023. PMID: 37648004
Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19.
Toro DM, da Silva-Neto PV, de Carvalho JCS, Fuzo CA, Pérez MM, Pimentel VE, Fraga-Silva TFC, Oliveira CNS, Caruso GR, Vilela AFL, Nobre-Azevedo P, Defelippo-Felippe TV, Argolo JGM, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, Rocha JJRD, Feres O, Costa GP, Maruyama SRC, Russo EMS, Fernandes APM, Santos IKFM, Malheiro A, Sadikot RT, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Trapé ÁA, Faccioli LH, Sorgi CA, ImmunoCovid Consortium Group. Toro DM, et al. Among authors: fraga silva tfc. Cells. 2023 Jul 26;12(15):1938. doi: 10.3390/cells12151938. Cells. 2023. PMID: 37566018 Free PMC article.
Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor.
Rodrigues D, Machado MR, Alves JV, Fraga-Silva TFC, Martins RB, Campos LCB, Francisco DF, Couto AES, Bonato VLD, Arruda E, Becari C, Auxiliadora-Martins M, Louzada-Júnior P, Costa RM, Tostes RC. Rodrigues D, et al. Among authors: fraga silva tfc. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H252-H263. doi: 10.1152/ajpheart.00096.2023. Epub 2023 Jun 16. Am J Physiol Heart Circ Physiol. 2023. PMID: 37327001 Free PMC article.
The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19.
de Carvalho JCS, da Silva-Neto PV, Toro DM, Fuzo CA, Nardini V, Pimentel VE, Pérez MM, Fraga-Silva TFC, Oliveira CNS, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, da Rocha JJR, Feres O, Vilar FC, Gaspar GG, Santos IKFM, Fernandes APM, Maruyama SR, Russo EMS, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Faccioli LH, Sorgi CA, On Behalf Of The ImmunoCovid Study Group. de Carvalho JCS, et al. Among authors: fraga silva tfc. Viruses. 2023 Feb 19;15(2):573. doi: 10.3390/v15020573. Viruses. 2023. PMID: 36851787 Free PMC article.
The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature.
Fuzo CA, Fraga-Silva TFC, Maruyama SR, Bastos VAF, Rogerio LA, Takamiya NT, da Silva-Neto PV, Pimentel VE, Toro DM, Pérez MM, de Carvalho JCS, Carmona-Garcia I, Oliveira CNS, Degiovani AM, Ostini FM, Constant LF, de Amorim AP, Vilar FC, Feitosa MR, Parra RS, da Rocha JJR, Feres O, Gaspar GG, Viana AL, Fernandes APM, Santos IKFM, Russo EMS, Cardoso CRB, Sorgi CA, Faccioli LH, Bonato VLD, Dias-Baruffi M; ImmunoCOVID study group. Fuzo CA, et al. Among authors: fraga silva tfc. Immunology. 2023 Jul;169(3):323-343. doi: 10.1111/imm.13631. Epub 2023 Mar 8. Immunology. 2023. PMID: 36740582
The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity.
Siekman SL, Pongracz T, Wang W, Nouta J, Kremsner PG, da Silva-Neto PV, Esen M, Kreidenweiss A, Held J, Trapé ÁA, Fendel R, de Miranda Santos IKF, Wuhrer M; ImmunoCovid Consortium. Siekman SL, et al. Front Immunol. 2022 Oct 18;13:993354. doi: 10.3389/fimmu.2022.993354. eCollection 2022. Front Immunol. 2022. PMID: 36389824 Free PMC article.
The Severity of COVID-19 Affects the Plasma Soluble Levels of the Immune Checkpoint HLA-G Molecule.
Cordeiro JFC, Fernandes TM, Toro DM, da Silva-Neto PV, Pimentel VE, Pérez MM, de Carvalho JCS, Fraga-Silva TFC, Oliveira CNS, Argolo JGM, Degiovani AM, Ostini FM, Puginna EF, da Silva JS, Santos IKFM, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Faccioli LH, Donadi EA, Sorgi CA, Fernandes APM, On Behalf Of The Immunocovid Study Group. Cordeiro JFC, et al. Among authors: fraga silva tfc. Int J Mol Sci. 2022 Aug 27;23(17):9736. doi: 10.3390/ijms23179736. Int J Mol Sci. 2022. PMID: 36077133 Free PMC article.
23 results