Teufel DP - Search Results

1

Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.

Teufel DP, Bennett G, Harrison H, van Rietschoten K, Pavan S, Stace C, Le Floch F, Van Bergen T, Vermassen E, Barbeaux P, Hu TT, Feyen JHM, Vanhove M. Teufel DP, et al. J Med Chem. 2018 Apr 12;61(7):2823-2836. doi: 10.1021/acs.jmedchem.7b01625. Epub 2018 Mar 15. J Med Chem. 2018. PMID: 29517911

2

Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.

Mudd GE, Brown A, Chen L, van Rietschoten K, Watcham S, Teufel DP, Pavan S, Lani R, Huxley P, Bennett GS. Mudd GE, et al. Among authors: teufel dp. J Med Chem. 2020 Apr 23;63(8):4107-4116. doi: 10.1021/acs.jmedchem.9b02129. Epub 2020 Apr 2. J Med Chem. 2020. PMID: 32202781

3

Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors.

Eder M, Pavan S, Bauder-Wüst U, van Rietschoten K, Baranski AC, Harrison H, Campbell S, Stace CL, Walker EH, Chen L, Bennett G, Mudd G, Schierbaum U, Leotta K, Haberkorn U, Kopka K, Teufel DP. Eder M, et al. Among authors: teufel dp. Cancer Res. 2019 Feb 15;79(4):841-852. doi: 10.1158/0008-5472.CAN-18-0238. Epub 2019 Jan 3. Cancer Res. 2019. PMID: 30606721

4

Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases.

Baeriswyl V, Rapley H, Pollaro L, Stace C, Teufel D, Walker E, Chen S, Winter G, Tite J, Heinis C. Baeriswyl V, et al. ChemMedChem. 2012 Jul;7(7):1173-6. doi: 10.1002/cmdc.201200071. Epub 2012 Apr 11. ChemMedChem. 2012. PMID: 22492508 No abstract available.

5

Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics.

Rajagopalan S, Andreeva A, Teufel DP, Freund SM, Fersht AR. Rajagopalan S, et al. Among authors: teufel dp. J Biol Chem. 2009 Aug 7;284(32):21728-37. doi: 10.1074/jbc.M109.006429. Epub 2009 Jun 12. J Biol Chem. 2009. PMID: 19525231 Free PMC article.

6

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2.

Teufel DP, Bycroft M, Fersht AR. Teufel DP, et al. Oncogene. 2009 May 21;28(20):2112-8. doi: 10.1038/onc.2009.71. Epub 2009 Apr 13. Oncogene. 2009. PMID: 19363523 Free PMC article.

7

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.

Teufel DP, Freund SM, Bycroft M, Fersht AR. Teufel DP, et al. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7009-14. doi: 10.1073/pnas.0702010104. Epub 2007 Apr 16. Proc Natl Acad Sci U S A. 2007. PMID: 17438265 Free PMC article.

8

Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.

Burge S, Teufel DP, Townsley FM, Freund SM, Bycroft M, Fersht AR. Burge S, et al. Among authors: teufel dp. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3142-7. doi: 10.1073/pnas.0900383106. Epub 2009 Feb 13. Proc Natl Acad Sci U S A. 2009. PMID: 19218448 Free PMC article.

9

Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53.

van Dieck J, Teufel DP, Jaulent AM, Fernandez-Fernandez MR, Rutherford TJ, Wyslouch-Cieszynska A, Fersht AR. van Dieck J, et al. Among authors: teufel dp. J Mol Biol. 2009 Dec 18;394(5):922-30. doi: 10.1016/j.jmb.2009.10.002. Epub 2009 Oct 9. J Mol Biol. 2009. PMID: 19819244

10

S100 proteins interact with the N-terminal domain of MDM2.

van Dieck J, Lum JK, Teufel DP, Fersht AR. van Dieck J, et al. Among authors: teufel dp. FEBS Lett. 2010 Aug 4;584(15):3269-74. doi: 10.1016/j.febslet.2010.06.024. Epub 2010 Jun 19. FEBS Lett. 2010. PMID: 20591429 Free article.

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