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An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Among authors: testolin g. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125
A synthetic antibiotic class overcoming bacterial multidrug resistance.
Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY, Ladley RP, Chatman K, Mankin AS, Polikanov YS, Myers AG. Mitcheltree MJ, et al. Among authors: testolin g. Nature. 2021 Nov;599(7885):507-512. doi: 10.1038/s41586-021-04045-6. Epub 2021 Oct 27. Nature. 2021. PMID: 34707295 Free PMC article.
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy.
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, Krull J, van den Heuvel J, Vassort A, Sordello S, Hamed MM, Elgaher WAM, Herrmann J, Hartmann RW, Müller R, Brönstrup M. Testolin G, et al. Chem Sci. 2019 Dec 10;11(5):1316-1334. doi: 10.1039/c9sc04769g. Chem Sci. 2019. PMID: 34123255 Free PMC article.
96 results