Tesmer J - Search Results

1

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.

Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG. Yen YC, et al. Among authors: tesmer jjg. Nat Struct Mol Biol. 2024 Apr 8. doi: 10.1038/s41594-024-01263-0. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38589608

2

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG. Chen CL, et al. Among authors: tesmer jjg. Nat Struct Mol Biol. 2024 Apr 2. doi: 10.1038/s41594-024-01265-y. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38565696

3

Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.

Chen Y, Sonawane A, Manda R, Gadi RK, Tesmer JJG, Ghosh AK. Chen Y, et al. Among authors: tesmer jjg. Eur J Med Chem. 2024 Jan 15;264:115931. doi: 10.1016/j.ejmech.2023.115931. Epub 2023 Nov 10. Eur J Med Chem. 2024. PMID: 38016297

4

Structural and dynamic changes in P-Rex1 upon activation by PIP₃ and inhibition by IP₄.

Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Gutkind JS, Cash JN, Tesmer JJG. Ravala SK, et al. Among authors: tesmer jjg. bioRxiv [Preprint]. 2024 Apr 17:2023.09.15.557836. doi: 10.1101/2023.09.15.557836. bioRxiv. 2024. PMID: 37745379 Free PMC article. Preprint.

5

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding.

Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. Chen Q, et al. Among authors: tesmer jjg. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549504. doi: 10.1101/2023.07.18.549504. bioRxiv. 2023. PMID: 37502840 Free PMC article. Preprint.

6

Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.

Schafer CT, Chen Q, Tesmer JJG, Handel TM. Schafer CT, et al. Among authors: tesmer jjg. Mol Pharmacol. 2023 Oct;104(4):174-186. doi: 10.1124/molpharm.123.000710. Epub 2023 Jul 20. Mol Pharmacol. 2023. PMID: 37474305 Free PMC article.

7

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade.

Walker MF, Zhang J, Steiner W, Ku PI, Zhu JF, Michaelson Z, Yen YC, Lee A, Long AB, Casey MJ, Poddar A, Nelson IB, Arveseth CD, Nagel F, Clough R, LaPotin S, Kwan KM, Schulz S, Stewart RA, Tesmer JJG, Caspary T, Subramanian R, Ge X, Myers BR. Walker MF, et al. Among authors: tesmer jjg. bioRxiv [Preprint]. 2024 Apr 18:2023.05.10.540226. doi: 10.1101/2023.05.10.540226. bioRxiv. 2024. PMID: 37214942 Free PMC article. Preprint.

8

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ.

Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG. Yen YC, et al. Among authors: tesmer jjg. bioRxiv [Preprint]. 2023 May 2:2023.05.02.539090. doi: 10.1101/2023.05.02.539090. bioRxiv. 2023. PMID: 37205557 Free PMC article. Preprint.

9

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG. Chen CL, et al. Among authors: tesmer jjg. bioRxiv [Preprint]. 2023 May 5:2023.05.04.539492. doi: 10.1101/2023.05.04.539492. bioRxiv. 2023. PMID: 37205329 Free PMC article. Updated. Preprint.

10

Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial.

Kymes SM, Oden NL, VanVeldhuisen PC, Scott IU, Ip MS, Blodi BA, King J; SCORE2 Investigator Group. Kymes SM, et al. JAMA Ophthalmol. 2023 Jun 1;141(6):554-561. doi: 10.1001/jamaophthalmol.2023.1463. JAMA Ophthalmol. 2023. PMID: 37166820

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