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Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.
Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM. Poe MM, et al. Among authors: teske ka. J Med Chem. 2016 Dec 8;59(23):10800-10806. doi: 10.1021/acs.jmedchem.6b01332. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933953 Free PMC article.
Novel VDR antagonists based on the GW0742 scaffold.
Teske KA, Bogart JW, Arnold LA. Teske KA, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):351-354. doi: 10.1016/j.bmcl.2017.12.041. Epub 2017 Dec 19. Bioorg Med Chem Lett. 2018. PMID: 29287957 Free PMC article.
Probing the Ligand-Binding Pocket of BTN3A1.
Poe MM, Agabiti SS, Liu C, Li V, Teske KA, Hsiao CC, Wiemer AJ. Poe MM, et al. Among authors: teske ka. J Med Chem. 2019 Jul 25;62(14):6814-6823. doi: 10.1021/acs.jmedchem.9b00825. Epub 2019 Jul 3. J Med Chem. 2019. PMID: 31268699 Free PMC article.
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Sidhu PS, et al. ACS Med Chem Lett. 2014 Feb 13;5(2):199-204. doi: 10.1021/ml400462j. ACS Med Chem Lett. 2014. PMID: 24799995 Free PMC article.
Biological evaluation and synthesis of calcitroic acid.
Yu OB, Webb DA, Di Milo ES, Mutchie TR, Teske KA, Chen T, Lin W, Peluso-Iltis C, Rochel N, Helmstädter M, Merk D, Arnold LA. Yu OB, et al. Among authors: teske ka. Bioorg Chem. 2021 Nov;116:105310. doi: 10.1016/j.bioorg.2021.105310. Epub 2021 Aug 28. Bioorg Chem. 2021. PMID: 34482171 Free PMC article. Review.
Anticancer activity of VDR-coregulator inhibitor PS121912.
Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Sidhu PS, et al. Cancer Chemother Pharmacol. 2014 Oct;74(4):787-98. doi: 10.1007/s00280-014-2549-y. Epub 2014 Aug 9. Cancer Chemother Pharmacol. 2014. PMID: 25107568 Free PMC article.
23 results