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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.
Mol Cell. 2019.
PMID: 30527540
Free PMC article.
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D.
Dettmer U, et al. Among authors: terry kantor e.
Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227.
Hum Mol Genet. 2017.
PMID: 28911198
Free PMC article.
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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U.
Imberdis T, et al. Among authors: terry kantor e.
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20760-20769. doi: 10.1073/pnas.1903216116. Epub 2019 Sep 23.
Proc Natl Acad Sci U S A. 2019.
PMID: 31548371
Free PMC article.
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Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U.
Terry-Kantor E, et al.
Int J Mol Sci. 2020 Jul 22;21(15):5193. doi: 10.3390/ijms21155193.
Int J Mol Sci. 2020.
PMID: 32707907
Free PMC article.
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Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U.
Tripathi A, et al. Among authors: terry kantor e.
J Neurosci. 2022 Mar 9;42(10):2116-2130. doi: 10.1523/JNEUROSCI.1881-21.2022. Epub 2022 Jan 27.
J Neurosci. 2022.
PMID: 35086904
Free PMC article.
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