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Structure-based engineering of a monoclonal antibody for improved solubility.
Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y. Wu SJ, et al. Among authors: teplyakov a. Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11. Protein Eng Des Sel. 2010. PMID: 20543007
Mechanisms of self-association of a human monoclonal antibody CNTO607.
Bethea D, Wu SJ, Luo J, Hyun L, Lacy ER, Teplyakov A, Jacobs SA, O'Neil KT, Gilliland GL, Feng Y. Bethea D, et al. Among authors: teplyakov a. Protein Eng Des Sel. 2012 Oct;25(10):531-7. doi: 10.1093/protein/gzs047. Epub 2012 Aug 22. Protein Eng Des Sel. 2012. PMID: 22915597
Conformational flexibility of an anti-IL-13 DARPin†.
Teplyakov A, Malia TJ, Obmolova G, Jacobs SA, O'Neil KT, Gilliland GL. Teplyakov A, et al. Protein Eng Des Sel. 2017 Jan;30(1):31-37. doi: 10.1093/protein/gzw059. Epub 2016 Nov 23. Protein Eng Des Sel. 2017. PMID: 27881684
Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.
Teplyakov A, Obmolova G, Rogers A, Gilliland GL. Teplyakov A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):229-32. doi: 10.1107/S1744309109054141. Epub 2010 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20208149 Free PMC article.
Coevolution of antibody stability and Vκ CDR-L3 canonical structure.
Luo J, Obmolova G, Huang A, Strake B, Teplyakov A, Malia T, Muzammil S, Zhao Y, Gilliland GL, Feng Y. Luo J, et al. Among authors: teplyakov a. J Mol Biol. 2010 Oct 1;402(4):708-19. doi: 10.1016/j.jmb.2010.08.009. Epub 2010 Aug 18. J Mol Biol. 2010. PMID: 20727359
His-tag binding by antibody C706 mimics β-amyloid recognition.
Teplyakov A, Obmolova G, Canziani G, Zhao Y, Gutshall L, Jung SS, Gilliland GL. Teplyakov A, et al. J Mol Recognit. 2011 Jul-Aug;24(4):570-5. doi: 10.1002/jmr.1069. Epub 2010 Sep 14. J Mol Recognit. 2011. PMID: 20842634
173 results