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Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.
Teplyakov A, Obmolova G, Rogers A, Gilliland GL. Teplyakov A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):229-32. doi: 10.1107/S1744309109054141. Epub 2010 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20208149 Free PMC article.
Human framework adaptation of a mouse anti-human IL-13 antibody.
Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC. Fransson J, et al. Among authors: teplyakov a. J Mol Biol. 2010 Apr 30;398(2):214-31. doi: 10.1016/j.jmb.2010.03.004. Epub 2010 Mar 10. J Mol Biol. 2010. PMID: 20226193
Structure-based engineering of a monoclonal antibody for improved solubility.
Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y. Wu SJ, et al. Among authors: teplyakov a. Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11. Protein Eng Des Sel. 2010. PMID: 20543007
On the domain pairing in chimeric antibodies.
Teplyakov A, Obmolova G, Carton JM, Gao W, Zhao Y, Gilliland GL. Teplyakov A, et al. Mol Immunol. 2010 Aug;47(14):2422-6. doi: 10.1016/j.molimm.2010.05.002. Mol Immunol. 2010. PMID: 20554002
Coevolution of antibody stability and Vκ CDR-L3 canonical structure.
Luo J, Obmolova G, Huang A, Strake B, Teplyakov A, Malia T, Muzammil S, Zhao Y, Gilliland GL, Feng Y. Luo J, et al. Among authors: teplyakov a. J Mol Biol. 2010 Oct 1;402(4):708-19. doi: 10.1016/j.jmb.2010.08.009. Epub 2010 Aug 18. J Mol Biol. 2010. PMID: 20727359
His-tag binding by antibody C706 mimics β-amyloid recognition.
Teplyakov A, Obmolova G, Canziani G, Zhao Y, Gutshall L, Jung SS, Gilliland GL. Teplyakov A, et al. J Mol Recognit. 2011 Jul-Aug;24(4):570-5. doi: 10.1002/jmr.1069. Epub 2010 Sep 14. J Mol Recognit. 2011. PMID: 20842634
Crystal structure of human germline antibody 3-23/B3.
Malia TJ, Obmolova G, Almagro JC, Gilliland GL, Teplyakov A. Malia TJ, et al. Among authors: teplyakov a. Mol Immunol. 2011 Jul;48(12-13):1586-8. doi: 10.1016/j.molimm.2011.04.020. Epub 2011 May 24. Mol Immunol. 2011. PMID: 21605907
Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.
Teplyakov A, Obmolova G, Malia T, Gilliland G. Teplyakov A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1165-7. doi: 10.1107/S1744309111027746. Epub 2011 Sep 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102019 Free PMC article.
173 results