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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: ten dijke p. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation.
van Dinther M, Visser N, de Gorter DJ, Doorn J, Goumans MJ, de Boer J, ten Dijke P. van Dinther M, et al. Among authors: ten dijke p. J Bone Miner Res. 2010 Jun;25(6):1208-15. doi: 10.1359/jbmr.091110. J Bone Miner Res. 2010. PMID: 19929436 Free article.
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.
de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Dévédec SE, Smit VT, van der Wal A, Van't Veer LJ, Cleton-Jansen AM, ten Dijke P, van de Water B. de Graauw M, et al. Among authors: ten dijke p. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308542 Free PMC article.
463 results