Temme L - Search Results

1

The second PI(3,5)P₂ binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transition.

Dellin M, Rohrbeck I, Asrani P, Schreiber JA, Ritter N, Glorius F, Wünsch B, Budde T, Temme L, Strünker T, Stallmeyer B, Tüttelmann F, Meuth SG, Spehr M, Matschke J, Steinbicker A, Gatsogiannis C, Stoll R, Strutz-Seebohm N, Seebohm G. Dellin M, et al. Among authors: temme l. Biol Chem. 2023 Feb 23;404(4):241-254. doi: 10.1515/hsz-2022-0247. Print 2023 Mar 28. Biol Chem. 2023. PMID: 36809224

2

Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.

Dey S, Temme L, Schreiber JA, Schepmann D, Frehland B, Lehmkuhl K, Strutz-Seebohm N, Seebohm G, Wünsch B. Dey S, et al. Among authors: temme l. Eur J Med Chem. 2017 Sep 29;138:552-564. doi: 10.1016/j.ejmech.2017.06.068. Epub 2017 Jul 1. Eur J Med Chem. 2017. PMID: 28704758

3

Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors.

Temme L, Schepmann D, Schreiber JA, Frehland B, Wünsch B. Temme L, et al. ChemMedChem. 2018 Mar 6;13(5):446-452. doi: 10.1002/cmdc.201700810. Epub 2018 Feb 16. ChemMedChem. 2018. PMID: 29377520

4

Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.

Temme L, Bechthold E, Schreiber JA, Gawaskar S, Schepmann D, Robaa D, Sippl W, Seebohm G, Wünsch B. Temme L, et al. Eur J Med Chem. 2020 Mar 15;190:112138. doi: 10.1016/j.ejmech.2020.112138. Epub 2020 Feb 10. Eur J Med Chem. 2020. PMID: 32070917

5

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold.

Gawaskar S, Temme L, Schreiber JA, Schepmann D, Bonifazi A, Robaa D, Sippl W, Strutz-Seebohm N, Seebohm G, Wünsch B. Gawaskar S, et al. Among authors: temme l. ChemMedChem. 2017 Aug 8;12(15):1212-1222. doi: 10.1002/cmdc.201700311. Epub 2017 Jul 27. ChemMedChem. 2017. PMID: 28749574

6

Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists.

Börgel F, Szermerski M, Schreiber JA, Temme L, Strutz-Seebohm N, Lehmkuhl K, Schepmann D, Ametamey SM, Seebohm G, Schmidt TJ, Wünsch B. Börgel F, et al. Among authors: temme l. ChemMedChem. 2018 Aug 10;13(15):1580-1587. doi: 10.1002/cmdc.201800214. Epub 2018 Jul 4. ChemMedChem. 2018. PMID: 29806151

7

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.

Temme L, Frehland B, Schepmann D, Robaa D, Sippl W, Wünsch B. Temme L, et al. Eur J Med Chem. 2018 Jan 20;144:672-681. doi: 10.1016/j.ejmech.2017.12.054. Epub 2017 Dec 18. Eur J Med Chem. 2018. PMID: 29289890

8

Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.

Temme L, Börgel F, Schepmann D, Robaa D, Sippl W, Daniliuc C, Wünsch B. Temme L, et al. Bioorg Med Chem. 2019 Dec 1;27(23):115146. doi: 10.1016/j.bmc.2019.115146. Epub 2019 Oct 8. Bioorg Med Chem. 2019. PMID: 31648876

9

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

Shuto Y, Thum S, Temme L, Schepmann D, Kitamura M, Wünsch B. Shuto Y, et al. Among authors: temme l. Medchemcomm. 2017 Mar 17;8(5):975-981. doi: 10.1039/c6md00621c. eCollection 2017 May 1. Medchemcomm. 2017. PMID: 30108812 Free PMC article.

10

GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists derived from 3-benzazepines: synthesis and pharmacological evaluation of benzo[7]annulen-7-amines.

Benner A, Bonifazi A, Shirataki C, Temme L, Schepmann D, Quaglia W, Shoji O, Watanabe Y, Daniliuc C, Wünsch B. Benner A, et al. Among authors: temme l. ChemMedChem. 2014 Apr;9(4):741-51. doi: 10.1002/cmdc.201300547. Epub 2014 Feb 23. ChemMedChem. 2014. PMID: 24677663

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