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Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G. Lirussi L, et al. Among authors: tell g. Mol Biol Cell. 2012 Oct;23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23. Mol Biol Cell. 2012. PMID: 22918947 Free PMC article.
Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen.
Sandomenico A, Focà A, Sanguigno L, Caporale A, Focà G, Pignalosa A, Corvino G, Caragnano A, Beltrami AP, Antoniali G, Tell G, Leonardi A, Ruvo M. Sandomenico A, et al. Among authors: tell g. MAbs. 2016 Nov/Dec;8(8):1575-1589. doi: 10.1080/19420862.2016.1225643. Epub 2016 Aug 25. MAbs. 2016. PMID: 27560983 Free PMC article.
616 results