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Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.
Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA. Gupton JT, et al. Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11. Bioorg Med Chem. 2017. PMID: 28433513 Free PMC article.
Further studies on vinamidinium salt amine exchange reactions, borohydride reductions and subsequent transformations.
Gupton JT, Telang N, Jia X, Giglio BC, Eaton JE, Barelli PJ, Hovaizi M, Hall KE, Welden RS, Keough MJ, Worrall EF, Finzel KL, Kluball EJ, Kanters RP, Smith TM, Smith SQ, Nunes SR, Wright MT, Birnstihl JM. Gupton JT, et al. Tetrahedron. 2010 Oct 30;66(44):8485-8493. doi: 10.1016/j.tet.2010.08.075. Tetrahedron. 2010. PMID: 21113324 Free PMC article.
The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones.
Gupton JT, Telang N, Banner EJ, Kluball EJ, Hall KE, Finzel KL, Jia X, Bates SR, Welden RS, Giglio BC, Eaton JE, Barelli PJ, Firich LT, Stafford JA, Coppock MB, Worrall EF, Kanters RP, Keertikar K, Osterman R. Gupton JT, et al. Tetrahedron. 2010 Nov 20;66(47):9113-9122. doi: 10.1016/j.tet.2010.09.080. Tetrahedron. 2010. PMID: 21135918 Free PMC article.
High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine.
Yu E, Mangunuru HPR, Telang NS, Kong CJ, Verghese J, Gilliland Iii SE, Ahmad S, Dominey RN, Gupton BF. Yu E, et al. Among authors: telang ns. Beilstein J Org Chem. 2018 Mar 8;14:583-592. doi: 10.3762/bjoc.14.45. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29623120 Free PMC article.