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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
Sci Transl Med. 2022 Nov 2;14(669):eabm3565. doi: 10.1126/scitranslmed.abm3565. Epub 2022 Nov 2.
Sci Transl Med. 2022.
PMID: 36322626
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex.
Zervopoulos SD, Boukouris AE, Saleme B, Haromy A, Tejay S, Sutendra G, Michelakis ED.
Zervopoulos SD, et al. Among authors: tejay s.
Mol Cell. 2022 Mar 3;82(5):1066-1077.e7. doi: 10.1016/j.molcel.2022.02.003.
Mol Cell. 2022.
PMID: 35245450
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