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Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.
Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Njomen E, Melillo B, Kutseikin S, Saez E, Cravatt BF, Teijaro JR, Wiseman RL, Bollong MJ. Stanton C, et al. Among authors: teijaro jr. ACS Chem Biol. 2024 Feb 16;19(2):254-265. doi: 10.1021/acschembio.3c00330. Epub 2024 Jan 10. ACS Chem Biol. 2024. PMID: 38198472
The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2.
Huang R, Warner Jenkins G, Kim Y, Stanfield RL, Singh A, Martinez-Yamout M, Kroon GJ, Torres JL, Jackson AM, Kelley A, Shaabani N, Zeng B, Bacica M, Chen W, Warner C, Radoicic J, Joh J, Dinali Perera K, Sang H, Kim T, Yao J, Zhao F, Sok D, Burton DR, Allen J, Harriman W, Mwangi W, Chung D, Teijaro JR, Ward AB, Dyson HJ, Wright PE, Wilson IA, Chang KO, McGregor D, Smider VV. Huang R, et al. Among authors: teijaro jr. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2303455120. doi: 10.1073/pnas.2303455120. Epub 2023 Sep 18. Proc Natl Acad Sci U S A. 2023. PMID: 37722054 Free PMC article.
Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Zhao F, Yuan M, Keating C, Shaabani N, Limbo O, Joyce C, Woehl J, Barman S, Burns A, Tran Q, Zhu X, Ricciardi M, Peng L, Smith J, Huang D, Briney B, Sok D, Nemazee D, Teijaro JR, Wilson IA, Burton DR, Jardine JG. Zhao F, et al. Among authors: teijaro jr. Sci Signal. 2023 Aug 15;16(798):eabk3516. doi: 10.1126/scisignal.abk3516. Epub 2023 Aug 15. Sci Signal. 2023. PMID: 37582161
Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.
Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Kutseikin S, Saez E, Teijaro JR, Wiseman RL, Bollong MJ. Stanton C, et al. Among authors: teijaro jr. bioRxiv [Preprint]. 2023 Jun 1:2023.06.01.543248. doi: 10.1101/2023.06.01.543248. bioRxiv. 2023. PMID: 37398499 Free PMC article. Updated. Preprint.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Among authors: teijaro jr. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731
84 results