Taylor SS - Search Results

1

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E. Röck R, et al. Among authors: taylor ss. Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31453322 Free PMC article.

2

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Hu J, et al. Among authors: taylor ss. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72. doi: 10.1073/pnas.1102554108. Epub 2011 Mar 25. Proc Natl Acad Sci U S A. 2011. PMID: 21441104 Free PMC article.

3

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.

Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Bachmann VA, et al. Among authors: taylor ss. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28. Proc Natl Acad Sci U S A. 2016. PMID: 27357676 Free PMC article.

4

Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation.

Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor SS. Bruystens JG, et al. Among authors: taylor ss. J Mol Biol. 2016 Dec 4;428(24 Pt B):4890-4904. doi: 10.1016/j.jmb.2016.10.033. Epub 2016 Nov 5. J Mol Biol. 2016. PMID: 27825928 Free PMC article.

5

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells.

Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS. Haushalter KJ, et al. Among authors: taylor ss. J Biol Chem. 2018 Mar 23;293(12):4411-4421. doi: 10.1074/jbc.M117.809988. Epub 2018 Jan 29. J Biol Chem. 2018. PMID: 29378851 Free PMC article.

6

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: taylor ss. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.

7

Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

Durick K, Gill GN, Taylor SS. Durick K, et al. Among authors: taylor ss. Mol Cell Biol. 1998 Apr;18(4):2298-308. doi: 10.1128/MCB.18.4.2298. Mol Cell Biol. 1998. PMID: 9528800 Free PMC article.

8

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Taylor SS, et al. Biochim Biophys Acta. 2008 Jan;1784(1):16-26. doi: 10.1016/j.bbapap.2007.10.002. Epub 2007 Oct 12. Biochim Biophys Acta. 2008. PMID: 17996741 Free PMC article. Review.

9

Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme.

Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. Boettcher AJ, et al. Among authors: taylor ss. Structure. 2011 Feb 9;19(2):265-76. doi: 10.1016/j.str.2010.12.005. Structure. 2011. PMID: 21300294 Free PMC article.

10

Allosteric activation of functionally asymmetric RAF kinase dimers.

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Among authors: taylor ss. Cell. 2013 Aug 29;154(5):1036-1046. doi: 10.1016/j.cell.2013.07.046. Cell. 2013. PMID: 23993095 Free PMC article.

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