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Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome.
Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH. Zhang Y, et al. Among authors: taylor rp. Kidney Int. 2020 Nov;98(5):1265-1274. doi: 10.1016/j.kint.2020.05.028. Epub 2020 Jun 12. Kidney Int. 2020. PMID: 32540405 Free PMC article.
A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement.
Lindorfer MA, Pawluczkowycz AW, Peek EM, Hickman K, Taylor RP, Parker CJ. Lindorfer MA, et al. Among authors: taylor rp. Blood. 2010 Mar 18;115(11):2283-91. doi: 10.1182/blood-2009-09-244285. Epub 2010 Jan 12. Blood. 2010. PMID: 20068220 Free article.
Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.
Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Jalal D, et al. Among authors: taylor rp. J Am Heart Assoc. 2018 Jul 13;7(14):e007818. doi: 10.1161/JAHA.117.007818. J Am Heart Assoc. 2018. PMID: 30006493 Free PMC article.
305 results