Taylor RJ - Search Results

1

High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.

Schwarz TC, Beier A, Ledolter K, Gossenreiter T, Höfurthner T, Hartl M, Baker TS, Taylor RJ, Konrat R. Schwarz TC, et al. Among authors: taylor rj. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2201910120. doi: 10.1073/pnas.2201910120. Epub 2023 Apr 7. Proc Natl Acad Sci U S A. 2023. PMID: 37027427 Free PMC article.

2

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR.

Amos STA, Schwarz TC, Shi J, Cossins BP, Baker TS, Taylor RJ, Konrat R, Sansom MSP. Amos STA, et al. Among authors: taylor rj. J Phys Chem B. 2021 Mar 25;125(11):2929-2941. doi: 10.1021/acs.jpcb.1c01281. Epub 2021 Mar 15. J Phys Chem B. 2021. PMID: 33719460 Free PMC article.

3

Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.

Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD. Veverka V, et al. Among authors: taylor rj. J Biol Chem. 2012 Nov 16;287(47):40043-50. doi: 10.1074/jbc.M112.405597. Epub 2012 Oct 1. J Biol Chem. 2012. PMID: 23027872 Free PMC article.

4

¹⁵N, ¹³C and ¹H resonance assignments and secondary structure determination of a variable heavy domain of a heavy chain antibody.

Prosser CE, Waters LC, Muskett FW, Veverka V, Addis PW, Griffin LM, Baker TS, Lawson AD, Wernery U, Kinne J, Henry AJ, Taylor RJ, Carr MD. Prosser CE, et al. Among authors: taylor rj. Biomol NMR Assign. 2014 Apr;8(1):113-6. doi: 10.1007/s12104-013-9464-8. Epub 2013 Jan 29. Biomol NMR Assign. 2014. PMID: 23359223

5

Nanodisc-Targeted STD NMR Spectroscopy Reveals Atomic Details of Ligand Binding to Lipid Environments.

Muñoz-García JC, Inacio Dos Reis R, Taylor RJ, Henry AJ, Watts A. Muñoz-García JC, et al. Among authors: taylor rj. Chembiochem. 2018 May 18;19(10):1022-1025. doi: 10.1002/cbic.201800078. Epub 2018 Apr 26. Chembiochem. 2018. PMID: 29537625

6

Conformational dynamics in interleukin 17A and 17F functional complexes is a key determinant of receptor A affinity and specificity.

Waters LC, Veverka V, Strong SL, Muskett FW, Dedi N, Lawson ADG, Prosser CE, Taylor RJ, Henry AJ, Carr MD. Waters LC, et al. Among authors: taylor rj. Cytokine. 2021 Jun;142:155476. doi: 10.1016/j.cyto.2021.155476. Epub 2021 Mar 9. Cytokine. 2021. PMID: 33706174

7

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.

Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD. Stöppler D, et al. PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. eCollection 2018 May. PLoS Biol. 2018. PMID: 29782488 Free PMC article.

8

The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor.

Landin EJB, Lovera S, de Fabritiis G, Kelm S, Mercier J, McMillan D, Sessions RB, Taylor RJ, Sands ZA, Joedicke L, Crump MP. Landin EJB, et al. Among authors: taylor rj. Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9399-9403. doi: 10.1002/anie.201902852. Epub 2019 Jun 5. Angew Chem Int Ed Engl. 2019. PMID: 31095849

9

Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.

Shaw DJ, Waters LC, Strong SL, Schulze MED, Greetham GM, Towrie M, Parker AW, Prosser CE, Henry AJ, Lawson ADG, Carr MD, Taylor RJ, Hunt NT, Muskett FW. Shaw DJ, et al. Among authors: taylor rj. Chem Sci. 2023 Jun 16;14(27):7524-7536. doi: 10.1039/d3sc00728f. eCollection 2023 Jul 12. Chem Sci. 2023. PMID: 37449080 Free PMC article.

10

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.

Patel S, Barkell AM, Gupta D, Strong SL, Bruton S, Muskett FW, Addis PW, Renshaw PS, Slocombe PM, Doyle C, Clargo A, Taylor RJ, Prosser CE, Henry AJ, Robinson MK, Waters LC, Holdsworth G, Carr MD. Patel S, et al. Among authors: taylor rj. J Biol Chem. 2018 Aug 3;293(31):12149-12166. doi: 10.1074/jbc.RA118.002918. Epub 2018 Jun 20. J Biol Chem. 2018. PMID: 29925589 Free PMC article.

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