Taylor IA - Search Results

1

The missing link: allostery and catalysis in the anti-viral protein SAMHD1.

Morris ER, Taylor IA. Morris ER, et al. Among authors: taylor ia. Biochem Soc Trans. 2019 Aug 30;47(4):1013-1027. doi: 10.1042/BST20180348. Epub 2019 Jul 11. Biochem Soc Trans. 2019. PMID: 31296733 Free PMC article. Review.

2

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M. Goldstone DC, et al. Among authors: taylor ia. Nature. 2011 Nov 6;480(7377):379-82. doi: 10.1038/nature10623. Nature. 2011. PMID: 22056990

3

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.

Arnold LH, Kunzelmann S, Webb MR, Taylor IA. Arnold LH, et al. Among authors: taylor ia. Antimicrob Agents Chemother. 2015 Jan;59(1):186-92. doi: 10.1128/AAC.03903-14. Epub 2014 Oct 20. Antimicrob Agents Chemother. 2015. PMID: 25331707 Free PMC article.

4

The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.

Morrissey C, Schwefel D, Ennis-Adeniran V, Taylor IA, Crow YJ, Webb M. Morrissey C, et al. Among authors: taylor ia. Biochem J. 2015 Feb 15;466(1):69-76. doi: 10.1042/BJ20140203. Biochem J. 2015. PMID: 25423367

5

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.

Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN. Arnold LH, et al. Among authors: taylor ia. PLoS Pathog. 2015 Oct 2;11(10):e1005194. doi: 10.1371/journal.ppat.1005194. eCollection 2015 Oct. PLoS Pathog. 2015. PMID: 26431200 Free PMC article.

6

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.

Ordonez P, Kunzelmann S, Groom HC, Yap MW, Weising S, Meier C, Bishop KN, Taylor IA, Stoye JP. Ordonez P, et al. Among authors: taylor ia. Sci Rep. 2017 Feb 21;7:42824. doi: 10.1038/srep42824. Sci Rep. 2017. PMID: 28220857 Free PMC article.

7

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.

Mlcochova P, Caswell SJ, Taylor IA, Towers GJ, Gupta RK. Mlcochova P, et al. Among authors: taylor ia. EMBO J. 2018 Jan 4;37(1):50-62. doi: 10.15252/embj.201796880. Epub 2017 Oct 30. EMBO J. 2018. PMID: 29084722 Free PMC article.

8

Positive selection in dNTPase SAMHD1 throughout mammalian evolution.

Monit C, Morris ER, Ruis C, Szafran B, Thiltgen G, Tsai MC, Mitchison NA, Bishop KN, Stoye JP, Taylor IA, Fassati A, Goldstein RA. Monit C, et al. Among authors: taylor ia. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18647-18654. doi: 10.1073/pnas.1908755116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451672 Free PMC article.

9

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: taylor ia. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

10

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: taylor ia. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

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