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Bifunctional crosslinking ligands for transthyretin.
Mangione PP, Deroo S, Ellmerich S, Bellotti V, Kolstoe S, Wood SP, Robinson CV, Smith MD, Tennent GA, Broadbridge RJ, Council CE, Thurston JR, Steadman VA, Vong AK, Swain CJ, Pepys MB, Taylor GW. Mangione PP, et al. Among authors: taylor gw. Open Biol. 2015 Sep;5(9):150105. doi: 10.1098/rsob.150105. Open Biol. 2015. PMID: 26400472 Free PMC article.
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, Robinson CV, Wood SP, Pepys MB. Kolstoe SE, et al. Among authors: taylor gw. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20483-8. doi: 10.1073/pnas.1008255107. Epub 2010 Nov 8. Proc Natl Acad Sci U S A. 2010. PMID: 21059958 Free PMC article.
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB. Bodin K, et al. Among authors: taylor gw. Nature. 2010 Nov 4;468(7320):93-7. doi: 10.1038/nature09494. Epub 2010 Oct 20. Nature. 2010. PMID: 20962779 Free PMC article.
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use.
Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW, Ellmerich S, Mangione PP, Tennent GA, Hutchinson WL, Millar DJ, Bennett G, More J, Evans D, Mistry Y, Poole S, Hawkins PN. Pepys MB, et al. Among authors: taylor gw. J Immunol Methods. 2012 Oct 31;384(1-2):92-102. doi: 10.1016/j.jim.2012.07.013. Epub 2012 Jul 31. J Immunol Methods. 2012. PMID: 22867744 Free PMC article.
Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.
Mangione PP, Esposito G, Relini A, Raimondi S, Porcari R, Giorgetti S, Corazza A, Fogolari F, Penco A, Goto Y, Lee YH, Yagi H, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Chiti F, Rolandi R, Taylor GW, Pepys MB, Stoppini M, Bellotti V. Mangione PP, et al. Among authors: taylor gw. J Biol Chem. 2013 Oct 25;288(43):30917-30. doi: 10.1074/jbc.M113.498857. Epub 2013 Sep 6. J Biol Chem. 2013. PMID: 24014031 Free PMC article.
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Mangione PP, Porcari R, Gillmore JD, Pucci P, Monti M, Porcari M, Giorgetti S, Marchese L, Raimondi S, Serpell LC, Chen W, Relini A, Marcoux J, Clatworthy IR, Taylor GW, Tennent GA, Robinson CV, Hawkins PN, Stoppini M, Wood SP, Pepys MB, Bellotti V. Mangione PP, et al. Among authors: taylor gw. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1539-44. doi: 10.1073/pnas.1317488111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24474780 Free PMC article.
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.
Marcoux J, Mangione PP, Porcari R, Degiacomi MT, Verona G, Taylor GW, Giorgetti S, Raimondi S, Sanglier-Cianférani S, Benesch JL, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Stoppini M, Robinson CV, Pepys MB, Bellotti V. Marcoux J, et al. Among authors: taylor gw. EMBO Mol Med. 2015 Oct;7(10):1337-49. doi: 10.15252/emmm.201505357. EMBO Mol Med. 2015. PMID: 26286619 Free PMC article.
Amyloid persistence in decellularized liver: biochemical and histopathological characterization.
Mazza G, Simons JP, Al-Shawi R, Ellmerich S, Urbani L, Giorgetti S, Taylor GW, Gilbertson JA, Hall AR, Al-Akkad W, Dhar D, Hawkins PN, De Coppi P, Pinzani M, Bellotti V, Mangione PP. Mazza G, et al. Among authors: taylor gw. Amyloid. 2016;23(1):1-7. doi: 10.3109/13506129.2015.1110518. Epub 2015 Dec 8. Amyloid. 2016. PMID: 26646718 Free PMC article.
468 results