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Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Al-Shabrawey M, Mussell R, Kahook K, Tawfik A, Eladl M, Sarthy V, Nussbaum J, El-Marakby A, Park SY, Gurel Z, Sheibani N, Maddipati KR. Al-Shabrawey M, et al. Among authors: tawfik a. Diabetes. 2011 Feb;60(2):614-24. doi: 10.2337/db10-0008. Epub 2011 Jan 12. Diabetes. 2011. PMID: 21228311 Free PMC article.
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.
Ibrahim AS, Elshafey S, Sellak H, Hussein KA, El-Sherbiny M, Abdelsaid M, Rizk N, Beasley S, Tawfik AM, Smith SB, Al-Shabrawey M. Ibrahim AS, et al. Among authors: tawfik am. J Lipid Res. 2015 Mar;56(3):599-611. doi: 10.1194/jlr.M056069. Epub 2015 Jan 17. J Lipid Res. 2015. PMID: 25598081 Free PMC article.
Targeting Neovascularization in Ischemic Retinopathy: Recent Advances.
Al-Shabrawey M, Elsherbiny M, Nussbaum J, Othman A, Megyerdi S, Tawfik A. Al-Shabrawey M, et al. Among authors: tawfik a. Expert Rev Ophthalmol. 2013 Jun;8(3):267-286. doi: 10.1586/eop.13.17. Expert Rev Ophthalmol. 2013. PMID: 25598837 Free PMC article.
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K, Baban B, Sheibani N, Wang MH, Tawfik A, Al-Shabrawey M. Ibrahim AS, et al. Among authors: tawfik a. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jun;1862(6):636-645. doi: 10.1016/j.bbalip.2017.03.010. Epub 2017 Mar 27. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28351645 Free PMC article.
437 results