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Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Gao S, Song L, Claff T, Woodson M, Sylvester K, Jing L, Weiße RH, Cheng Y, Sträter N, Schäkel L, Gütschow M, Ye B, Yang M, Zhang T, Kang D, Toth K, Tavis J, Tollefson AE, Müller CE, Zhan P, Liu X. Gao S, et al. Among authors: tavis j. J Med Chem. 2022 Dec 22;65(24):16902-16917. doi: 10.1021/acs.jmedchem.2c01716. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475694
The duck hepatitis B virus polymerase is activated by its RNA packaging signal, epsilon.
Tavis JE, Massey B, Gong Y. Tavis JE, et al. J Virol. 1998 Jul;72(7):5789-96. doi: 10.1128/JVI.72.7.5789-5796.1998. J Virol. 1998. PMID: 9621038 Free PMC article.
We have previously presented evidence for a third essential role for epsilon, that of an essential cofactor in the maturation of the viral polymerase (J. E. Tavis and D. Ganem, J. Virol. 70:5741-5750, 1996). In this case, binding of epsilon to the polymerase …
We have previously presented evidence for a third essential role for epsilon, that of an essential cofactor in the maturation of the viral p …
A research agenda for curing chronic hepatitis B virus infection.
Alter H, Block T, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Guo H, Guo JT, Hoshida Y, Hu J, Kowdley KV, Li W, Liang J, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo J, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F. Alter H, et al. Among authors: tavis j. Hepatology. 2018 Mar;67(3):1127-1131. doi: 10.1002/hep.29509. Epub 2018 Jan 24. Hepatology. 2018. PMID: 28877549 Free PMC article. No abstract available.
129 results