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Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage.
Amorim R, Cagide F, Tavares LC, Simões RF, Soares P, Benfeito S, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J. Amorim R, et al. Among authors: tavares lc. Free Radic Biol Med. 2022 Feb 1;179:119-132. doi: 10.1016/j.freeradbiomed.2021.12.304. Epub 2021 Dec 22. Free Radic Biol Med. 2022. PMID: 34954022
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.
Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, Simões RF, Karkucinska-Wieckowska A, Viegas I, Szymanska S, Dąbrowski M, Janikiewicz J, Cunha-Oliveira T, Dobrzyń A, Jones JG, Borges F, Wieckowski MR, Oliveira PJ. Amorim R, et al. Among authors: tavares lc. Redox Biol. 2022 Sep;55:102400. doi: 10.1016/j.redox.2022.102400. Epub 2022 Jul 16. Redox Biol. 2022. PMID: 35863265 Free PMC article.
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