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Year Number of Results
2013 1
2015 2
2016 3
2017 2
2018 3
2019 2
2020 1
2021 2
2022 1
2023 5
2024 2

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23 results

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Page 1
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Fried W, et al. Among authors: kent t. Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1. Nat Commun. 2024. PMID: 38580648 Free PMC article.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT. Calbert ML, et al. Among authors: kent t. Mol Cancer Ther. 2024 May 2;23(5):683-699. doi: 10.1158/1535-7163.MCT-23-0487. Mol Cancer Ther. 2024. PMID: 38064712
Correction: Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing.
Demidova EV, Serebriiskii IG, Vlasenkova R, Kelow S, Andrake MD, Hartman TR, Kent T, Virtucio J, Rosen GL, Pomerantz RT, Dunbrack RL Jr, Golemis EA, Hall MJ, Chen DYT, Daly MB, Arora S. Demidova EV, et al. Among authors: kent t. BMC Genomics. 2023 Jul 10;24(1):388. doi: 10.1186/s12864-023-09486-z. BMC Genomics. 2023. PMID: 37430226 Free PMC article. No abstract available.
Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing.
Demidova EV, Serebriiskii IG, Vlasenkova R, Kelow S, Andrake MD, Hartman TR, Kent T, Virtucio J, Rosen GL, Pomerantz RT, Dunbrack RL Jr, Golemis EA, Hall MJ, Chen DYT, Daly MB, Arora S. Demidova EV, et al. Among authors: kent t. BMC Genomics. 2023 Apr 24;24(1):212. doi: 10.1186/s12864-023-09310-8. BMC Genomics. 2023. PMID: 37095444 Free PMC article.
Author Correction: Polλ promotes microhomology-mediated end-joining.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Chandramouly G, et al. Among authors: kent t. Nat Struct Mol Biol. 2023 Jul;30(7):1048. doi: 10.1038/s41594-023-00993-x. Nat Struct Mol Biol. 2023. PMID: 37059901 No abstract available.
Polλ promotes microhomology-mediated end-joining.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Chandramouly G, et al. Among authors: kent t. Nat Struct Mol Biol. 2023 Jan;30(1):107-114. doi: 10.1038/s41594-022-00895-4. Epub 2022 Dec 19. Nat Struct Mol Biol. 2023. PMID: 36536104 Free PMC article.
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair.
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT. Chandramouly G, et al. Among authors: kent t. Sci Adv. 2021 Jun 11;7(24):eabf1771. doi: 10.1126/sciadv.abf1771. Print 2021 Jun. Sci Adv. 2021. PMID: 34117057 Free PMC article.
Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Black SJ, et al. Among authors: kent t. Nat Commun. 2020 Apr 9;11(1):1831. doi: 10.1038/s41467-020-15551-y. Nat Commun. 2020. PMID: 32273507 Free PMC article.
23 results