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GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
Heitzeneder S, Bosse KR, Zhu Z, Zhelev D, Majzner RG, Radosevich MT, Dhingra S, Sotillo E, Buongervino S, Pascual-Pasto G, Garrigan E, Xu P, Huang J, Salzer B, Delaidelli A, Raman S, Cui H, Martinez B, Bornheimer SJ, Sahaf B, Alag A, Fetahu IS, Hasselblatt M, Parker KR, Anbunathan H, Hwang J, Huang M, Sakamoto K, Lacayo NJ, Klysz DD, Theruvath J, Vilches-Moure JG, Satpathy AT, Chang HY, Lehner M, Taschner-Mandl S, Julien JP, Sorensen PH, Dimitrov DS, Maris JM, Mackall CL. Heitzeneder S, et al. Cancer Cell. 2022 Jan 10;40(1):53-69.e9. doi: 10.1016/j.ccell.2021.12.005. Epub 2021 Dec 30. Cancer Cell. 2022. PMID: 34971569 Free PMC article.
Independent Validation of a Deep Learning nnU-Net Tool for Neuroblastoma Detection and Segmentation in MR Images.
Veiga-Canuto D, Cerdà-Alberich L, Jiménez-Pastor A, Carot Sierra JM, Gomis-Maya A, Sangüesa-Nebot C, Fernández-Patón M, Martínez de Las Heras B, Taschner-Mandl S, Düster V, Pötschger U, Simon T, Neri E, Alberich-Bayarri Á, Cañete A, Hero B, Ladenstein R, Martí-Bonmatí L. Veiga-Canuto D, et al. Among authors: taschner mandl s. Cancers (Basel). 2023 Mar 6;15(5):1622. doi: 10.3390/cancers15051622. Cancers (Basel). 2023. PMID: 36900410 Free PMC article.
Neuroblastoma and the epigenome.
Fetahu IS, Taschner-Mandl S. Fetahu IS, et al. Cancer Metastasis Rev. 2021 Mar;40(1):173-189. doi: 10.1007/s10555-020-09946-y. Epub 2021 Jan 6. Cancer Metastasis Rev. 2021. PMID: 33404859 Free PMC article. Review.
Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis.
Fetahu IS, Esser-Skala W, Dnyansagar R, Sindelar S, Rifatbegovic F, Bileck A, Skos L, Bozsaky E, Lazic D, Shaw L, Tötzl M, Tarlungeanu D, Bernkopf M, Rados M, Weninger W, Tomazou EM, Bock C, Gerner C, Ladenstein R, Farlik M, Fortelny N, Taschner-Mandl S. Fetahu IS, et al. Among authors: taschner mandl s. Nat Commun. 2023 Jun 26;14(1):3620. doi: 10.1038/s41467-023-39210-0. Nat Commun. 2023. PMID: 37365178 Free PMC article.
Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma.
Bogen D, Wei JS, Azorsa DO, Ormanoglu P, Buehler E, Guha R, Keller JM, Mathews Griner LA, Ferrer M, Song YK, Liao H, Mendoza A, Gryder BE, Sindri S, He J, Wen X, Zhang S, Shern JF, Yohe ME, Taschner-Mandl S, Shohet JM, Thomas CJ, Martin SE, Ambros PF, Khan J. Bogen D, et al. Oncotarget. 2015 Nov 3;6(34):35247-62. doi: 10.18632/oncotarget.6208. Oncotarget. 2015. PMID: 26497213 Free PMC article.
35 results