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Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Tacconi EM, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, Folio C, Moore J, Kopp A, Baguña Torres J, Sneddon D, Green M, Dedic S, Lee JW, Batra AS, Rueda OM, Bruna A, Leonetti C, Caldas C, Cornelissen B, Brino L, Ryan A, Biroccio A, Tarsounas M. Tacconi EM, et al. Among authors: tarsounas m. EMBO Mol Med. 2019 Jul;11(7):e9982. doi: 10.15252/emmm.201809982. Epub 2019 May 24. EMBO Mol Med. 2019. PMID: 31273933 Free PMC article.
p53 prevents entry into mitosis with uncapped telomeres.
Thanasoula M, Escandell JM, Martinez P, Badie S, Muñoz P, Blasco MA, Tarsounas M. Thanasoula M, et al. Among authors: tarsounas m. Curr Biol. 2010 Mar 23;20(6):521-6. doi: 10.1016/j.cub.2010.01.046. Epub 2010 Mar 11. Curr Biol. 2010. PMID: 20226664 Free PMC article.
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M. Badie S, et al. Among authors: tarsounas m. Nat Struct Mol Biol. 2010 Dec;17(12):1461-9. doi: 10.1038/nsmb.1943. Epub 2010 Nov 14. Nat Struct Mol Biol. 2010. PMID: 21076401 Free PMC article.
How homologous recombination maintains telomere integrity.
Tacconi EM, Tarsounas M. Tacconi EM, et al. Among authors: tarsounas m. Chromosoma. 2015 Jun;124(2):119-30. doi: 10.1007/s00412-014-0497-2. Epub 2014 Nov 29. Chromosoma. 2015. PMID: 25430998 Review.
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
Zimmer J, Tacconi EMC, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M. Zimmer J, et al. Among authors: tarsounas m. Mol Cell. 2016 Feb 4;61(3):449-460. doi: 10.1016/j.molcel.2015.12.004. Epub 2015 Dec 31. Mol Cell. 2016. PMID: 26748828 Free PMC article.
61 results