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HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Ledneczki I, Horváth A, Tapolcsányi P, Éles J, Molnár KD, Vágó I, Visegrády A, Kiss L, Szigetvári Á, Kóti J, Krámos B, Mahó S, Holm P, Kolok S, Fodor L, Thán M, Kostyalik D, Balázs O, Vastag M, Greiner I, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: tapolcsanyi p. Eur J Med Chem. 2021 Oct 15;222:113560. doi: 10.1016/j.ejmech.2021.113560. Epub 2021 May 29. Eur J Med Chem. 2021. PMID: 34111828
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists.
Ledneczki I, Tapolcsányi P, Gábor E, Éles J, Greiner I, Schmidt É, Némethy Z, Kedves RS, Balázs O, Román V, Lévay G, Mahó S. Ledneczki I, et al. Among authors: tapolcsanyi p. Bioorg Med Chem Lett. 2017 Oct 1;27(19):4525-4530. doi: 10.1016/j.bmcl.2017.08.060. Epub 2017 Sep 1. Bioorg Med Chem Lett. 2017. PMID: 28888822
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
Ledneczki I, Tapolcsányi P, Gábor E, Visegrády A, Vass M, Éles J, Holm P, Horváth A, Pocsai A, Mahó S, Greiner I, Krámos B, Béni Z, Kóti J, Káncz AE, Thán M, Kolok S, Laszy J, Balázs O, Bugovits G, Nagy J, Vastag M, Szájli Á, Bozó É, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: tapolcsanyi p. Eur J Med Chem. 2021 Mar 15;214:113189. doi: 10.1016/j.ejmech.2021.113189. Epub 2021 Jan 14. Eur J Med Chem. 2021. PMID: 33540354
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
Ledneczki I, Némethy Z, Molnár KD, Tapolcsányi P, Ilkei V, Vágó I, Kolok S, Thán M, Laszy J, Balázs O, Krámos B, Szigetvári Á, Bata I, Makó A, Visegrády A, Fodor L, Vastag M, Lévay G, Lendvai B, Greiner I, Éles J. Ledneczki I, et al. Among authors: tapolcsanyi p. J Med Chem. 2023 Dec 14;66(23):16276-16302. doi: 10.1021/acs.jmedchem.3c01635. Epub 2023 Nov 21. J Med Chem. 2023. PMID: 37989278
Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists.
Ledneczki I, Tapolcsányi P, Gábor E, Éles J, Barabás J, Béni Z, Varga B, Balázs O, Román V, Fodor L, Szikra J, Vastag M, Lévay G, Schmidt É, Lendvai B, Greiner I, Kiss B, Némethy Z, Mahó S. Ledneczki I, et al. Among authors: tapolcsanyi p. J Med Chem. 2024 Mar 14;67(5):3643-3667. doi: 10.1021/acs.jmedchem.3c02117. Epub 2024 Feb 23. J Med Chem. 2024. PMID: 38393759
Glycine transporter type-1 and its inhibitors.
Harsing LG Jr, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P. Harsing LG Jr, et al. Among authors: tapolcsanyi p. Curr Med Chem. 2006;13(9):1017-44. doi: 10.2174/092986706776360932. Curr Med Chem. 2006. PMID: 16611082 Review.
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, Pieters L. Van Baelen G, et al. Among authors: tapolcsanyi p. Bioorg Med Chem. 2009 Oct 15;17(20):7209-17. doi: 10.1016/j.bmc.2009.08.057. Epub 2009 Sep 3. Bioorg Med Chem. 2009. PMID: 19781948
Sarcosine-Based Glycine Transporter Type-1 (GlyT-1) Inhibitors Containing Pyridazine Moiety: A Further Search for Drugs with Potential to Influence Schizophrenia Negative Symptoms.
Harsing LG Jr, Timar J, Szabo G, Udvari S, Nagy KM, Marko B, Zsilla G, Czompa A, Tapolcsanyi P, Kocsis A, Matyus P. Harsing LG Jr, et al. Among authors: tapolcsanyi p. Curr Pharm Des. 2015;21(17):2291-303. doi: 10.2174/1381612821666150109125623. Curr Pharm Des. 2015. PMID: 25578890
14 results