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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA. Kerry J, et al. Among authors: tapia m. Cell Rep. 2017 Jan 10;18(2):482-495. doi: 10.1016/j.celrep.2016.12.054. Cell Rep. 2017. PMID: 28076791 Free PMC article.
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.
Wu Q, Ferry QRV, Baeumler TA, Michaels YS, Vitsios DM, Habib O, Arnold R, Jiang X, Maio S, Steinkraus BR, Tapia M, Piazza P, Xu N, Holländer GA, Milne TA, Kim JS, Enright AJ, Bassett AR, Fulga TA. Wu Q, et al. Among authors: tapia m. Nat Commun. 2017 Dec 13;8(1):2109. doi: 10.1038/s41467-017-00686-2. Nat Commun. 2017. PMID: 29235467 Free PMC article.
BET inhibition disrupts transcription but retains enhancer-promoter contact.
Crump NT, Ballabio E, Godfrey L, Thorne R, Repapi E, Kerry J, Tapia M, Hua P, Lagerholm C, Filippakopoulos P, Davies JOJ, Milne TA. Crump NT, et al. Among authors: tapia m. Nat Commun. 2021 Jan 11;12(1):223. doi: 10.1038/s41467-020-20400-z. Nat Commun. 2021. PMID: 33431820 Free PMC article.
A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.
Harman JR, Thorne R, Jamilly M, Tapia M, Crump NT, Rice S, Beveridge R, Morrissey E, de Bruijn MFTR, Roberts I, Roy A, Fulga TA, Milne TA. Harman JR, et al. Among authors: tapia m. Genome Res. 2021 Jul;31(7):1159-1173. doi: 10.1101/gr.268490.120. Epub 2021 Jun 4. Genome Res. 2021. PMID: 34088716 Free PMC article.
Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard.
Theilgaard-Mönch K, Pundhir S, Reckzeh K, Su J, Tapia M, Furtwängler B, Jendholm J, Jakobsen JS, Hasemann MS, Knudsen KJ, Cowland JB, Fossum A, Schoof E, Schuster MB, Porse BT. Theilgaard-Mönch K, et al. Among authors: tapia m. Nat Commun. 2022 Jun 23;13(1):3595. doi: 10.1038/s41467-022-31332-1. Nat Commun. 2022. PMID: 35739121 Free PMC article.
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes.
Trempenau ML, Schuster MB, Pundhir S, Pereira MA, Kalvisa A, Tapia M, Su J, Ge Y, de Boer B, Balhuizen A, Bagger FO, Shliaha P, Sroczynska P, Walfridsson J, Grønbæk K, Theilgaard-Mönch K, Jensen ON, Helin K, Porse BT. Trempenau ML, et al. Among authors: tapia m. Leukemia. 2023 Mar;37(3):593-605. doi: 10.1038/s41375-023-01810-6. Epub 2023 Jan 12. Leukemia. 2023. PMID: 36631623 Free PMC article.
511 results