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Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures.
Tapella L, Dematteis G, Ruffinatti FA, Ponzoni L, Fiordaliso F, Corbelli A, Albanese E, Pistolato B, Pagano J, Barberis E, Marengo E, Balducci C, Forloni G, Verpelli C, Sala C, Distasi C, Sala M, Manfredi M, Genazzani AA, Lim D. Tapella L, et al. Cell Calcium. 2021 Dec;100:102480. doi: 10.1016/j.ceca.2021.102480. Epub 2021 Sep 26. Cell Calcium. 2021. PMID: 34607180
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.
Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G. Balducci C, et al. Among authors: tapella l. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. doi: 10.1073/pnas.0911829107. Epub 2010 Jan 19. Proc Natl Acad Sci U S A. 2010. PMID: 20133875 Free PMC article.
Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.
Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, Comerio L, Tapella L, Baracchi F, Fernández-Borges N, Mangieri M, Bisighini C, Beznoussenko GV, Paladini A, Balducci C, Micotti E, Forloni G, Castilla J, Fiordaliso F, Tagliavini F, Imeri L, Chiesa R. Bouybayoune I, et al. Among authors: tapella l. PLoS Pathog. 2015 Apr 16;11(4):e1004796. doi: 10.1371/journal.ppat.1004796. eCollection 2015 Apr. PLoS Pathog. 2015. PMID: 25880443 Free PMC article.
The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers.
Stravalaci M, Tapella L, Beeg M, Rossi A, Joshi P, Pizzi E, Mazzanti M, Balducci C, Forloni G, Biasini E, Salmona M, Diomede L, Chiesa R, Gobbi M. Stravalaci M, et al. Among authors: tapella l. J Alzheimers Dis. 2016 Jul 6;53(4):1485-97. doi: 10.3233/JAD-150882. J Alzheimers Dis. 2016. PMID: 27392850 Free PMC article.
Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+ /K+ ATPase.
Tapella L, Soda T, Mapelli L, Bortolotto V, Bondi H, Ruffinatti FA, Dematteis G, Stevano A, Dionisi M, Ummarino S, Di Ruscio A, Distasi C, Grilli M, Genazzani AA, D'Angelo E, Moccia F, Lim D. Tapella L, et al. Glia. 2020 Mar;68(3):543-560. doi: 10.1002/glia.23737. Epub 2019 Oct 18. Glia. 2020. PMID: 31626368 Free article.
Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.
Rocchio F, Tapella L, Manfredi M, Chisari M, Ronco F, Ruffinatti FA, Conte E, Canonico PL, Sortino MA, Grilli M, Marengo E, Genazzani AA, Lim D. Rocchio F, et al. Among authors: tapella l. Cell Death Dis. 2020 Apr 16;11(4):236. doi: 10.1038/s41419-020-2451-y. Cell Death Dis. 2020. PMID: 32300109 Free PMC article.
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