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Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids.
Bioorg Chem. 2022 Feb;119:105578. doi: 10.1016/j.bioorg.2021.105578. Epub 2021 Dec 23.
Bioorg Chem. 2022.
PMID: 34979464
Potent antitumor activity of novel taxoids in anaplastic thyroid cancer.
Wang M, Wang C, Feng C, Guo W, Chen H, Liu B, Li E, Liu W, Taouil A, Ojima I, Hou P.
Wang M, et al.
Endocrine. 2022 Feb;75(2):465-477. doi: 10.1007/s12020-021-02880-1. Epub 2021 Sep 30.
Endocrine. 2022.
PMID: 34591230
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SAR study on Novel truxillic acid monoester-Based inhibitors of fatty acid binding proteins as Next-Generation antinociceptive agents.
Wang H, Taouil A, Awwa M, Clement T, Zhu C, Kim J, Rendina D, Jayanetti K, Maharaj A, Wang L, Bogdan D, Pepe A, Kaczocha M, Ojima I.
Wang H, et al.
Bioorg Chem. 2022 Dec;129:106184. doi: 10.1016/j.bioorg.2022.106184. Epub 2022 Sep 30.
Bioorg Chem. 2022.
PMID: 36244323
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Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CH3, 3-CF3O and 3-CHF2O groups at the C2-benzoate position.
Wang C, Wang X, Sun Y, Taouil AK, Yan S, Botchkina GI, Ojima I.
Wang C, et al. Among authors: taouil ak.
Bioorg Chem. 2020 Jan;95:103523. doi: 10.1016/j.bioorg.2019.103523. Epub 2019 Dec 20.
Bioorg Chem. 2020.
PMID: 31911305
Free PMC article.
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A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance in breast cancer cells.
Rong D, Wang C, Zhang X, Wei Y, Zhang M, Liu D, Farhan H, Momen Ali SA, Liu Y, Taouil A, Guo W, Wang Y, Ojima I, Yang S, Wang H.
Rong D, et al.
Cancer Lett. 2020 Oct 28;491:36-49. doi: 10.1016/j.canlet.2020.06.025. Epub 2020 Jul 27.
Cancer Lett. 2020.
PMID: 32730778
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Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
Pereira de Sa N, Taouil A, Kim J, Clement T, Hoffmann RM, Burke JE, Rizzo RC, Ojima I, Del Poeta M, Airola MV.
Pereira de Sa N, et al.
Nat Commun. 2021 Oct 7;12(1):5885. doi: 10.1038/s41467-021-26163-5.
Nat Commun. 2021.
PMID: 34620873
Free PMC article.
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