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Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.
Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. Wittrahm R, et al. Among authors: tanzi re. Neurobiol Dis. 2023 Jun 15;182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. Neurobiol Dis. 2023. PMID: 37120095 Free article.
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.
Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. Boyarko B, et al. Among authors: tanzi re. Front Pharmacol. 2023 Aug 4;14:1190402. doi: 10.3389/fphar.2023.1190402. eCollection 2023. Front Pharmacol. 2023. PMID: 37601062 Free PMC article. Review.
Accelerating the in vitro emulation of Alzheimer's disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model.
Ko EC, Spitz S, Pramotton FM, Barr OM, Xu C, Pavlou G, Zhang S, Tsai A, Maaser-Hecker A, Jorfi M, Choi SH, Tanzi RE, Kamm RD. Ko EC, et al. Among authors: tanzi re. Front Bioeng Biotechnol. 2023 Oct 9;11:1251195. doi: 10.3389/fbioe.2023.1251195. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37901842 Free PMC article.
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Bosch ME, et al. Among authors: tanzi re. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Mol Neurodegener. 2024. PMID: 38365827 Free PMC article.
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.
Lathe R, Schultek NM, Balin BJ, Ehrlich GD, Auber LA, Perry G, Breitschwerdt EB, Corry DB, Doty RL, Rissman RA, Nara PL, Itzhaki R, Eimer WA, Tanzi RE; Intracell Research Group Consortium Collaborators. Lathe R, et al. Among authors: tanzi re. Alzheimers Dement. 2023 Nov;19(11):5209-5231. doi: 10.1002/alz.13076. Epub 2023 Jun 7. Alzheimers Dement. 2023. PMID: 37283269 Free PMC article. Review.
523 results