Tang TT - Search Results

1

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma.

Laraba L, Hillson L, de Guibert JG, Hewitt A, Jaques MR, Tang TT, Post L, Ercolano E, Rai G, Yang SM, Jagger DJ, Woznica W, Edwards P, Shivane AG, Hanemann CO, Parkinson DB. Laraba L, et al. Among authors: tang tt. Brain. 2023 Apr 19;146(4):1697-1713. doi: 10.1093/brain/awac342. Brain. 2023. PMID: 36148553 Free PMC article.

2

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma.

Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Tang TT, et al. Mol Cancer Ther. 2021 Jun;20(6):986-998. doi: 10.1158/1535-7163.MCT-20-0717. Epub 2021 Apr 13. Mol Cancer Ther. 2021. PMID: 33850002

3

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors.

Edwards AC, Stalnecker CA, Jean Morales A, Taylor KE, Klomp JE, Klomp JA, Waters AM, Sudhakar N, Hallin J, Tang TT, Olson P, Post L, Christensen JG, Cox AD, Der CJ. Edwards AC, et al. Among authors: tang tt. Cancer Res. 2023 Dec 15;83(24):4112-4129. doi: 10.1158/0008-5472.CAN-23-2994. Cancer Res. 2023. PMID: 37934103

4

Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.

Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG. Haderk F, et al. Among authors: tang tt. Nat Commun. 2024 May 3;15(1):3741. doi: 10.1038/s41467-024-47423-0. Nat Commun. 2024. PMID: 38702301 Free PMC article.

5

Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER⁺ breast cancer.

Ma S, Tang T, Probst G, Konradi A, Jin C, Li F, Gutkind JS, Fu XD, Guan KL. Ma S, et al. Nat Commun. 2022 Feb 25;13(1):1061. doi: 10.1038/s41467-022-28691-0. Nat Commun. 2022. PMID: 35217640 Free PMC article.

6

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.

Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG. Mukhopadhyay S, et al. Among authors: tang tt. Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729. Cancer Res. 2023. PMID: 37729426

7

Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides.

Li FL, Fu V, Liu G, Tang T, Konradi AW, Peng X, Kemper E, Cravatt BF, Franklin JM, Wu Z, Mayfield J, Dixon JE, Gerwick WH, Guan KL. Li FL, et al. Nat Chem Biol. 2022 Oct;18(10):1076-1086. doi: 10.1038/s41589-022-01061-z. Epub 2022 Jul 4. Nat Chem Biol. 2022. PMID: 35788180

8

Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition.

Kim YJ, Pemberton JG, Eisenreichova A, Mandal A, Koukalova A, Rohilla P, Sohn M, Konradi AW, Tang TT, Boura E, Balla T. Kim YJ, et al. Among authors: tang tt. EMBO J. 2024 Apr 16. doi: 10.1038/s44318-024-00096-3. Online ahead of print. EMBO J. 2024. PMID: 38627600 Free article.

9

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.

Chen W, Tang T, Eastham-Anderson J, Dunlap D, Alicke B, Nannini M, Gould S, Yauch R, Modrusan Z, DuPree KJ, Darbonne WC, Plowman G, de Sauvage FJ, Callahan CA. Chen W, et al. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9589-94. doi: 10.1073/pnas.1017945108. Epub 2011 May 19. Proc Natl Acad Sci U S A. 2011. PMID: 21597001 Free PMC article.

10

HIF-1α and adaptor protein LIM and senescent cell antigen-like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II-induced hypertension.

Ni WJ, Li ZL, Wen XL, Ji JL, Liu H, Yin Q, Jiang LY, Zhang YL, Wen Y, Tang TT, Jiang W, Lv LL, Gan WH, Liu BC, Wang B. Ni WJ, et al. Among authors: tang tt. Br J Pharmacol. 2024 May 3. doi: 10.1111/bph.16358. Online ahead of print. Br J Pharmacol. 2024. PMID: 38698737

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