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Metabolic activation of tachysterol3 to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors.
Slominski AT, Kim TK, Slominski RM, Song Y, Janjetovic Z, Podgorska E, Reddy SB, Song Y, Raman C, Tang EKY, Fabisiak A, Brzeminski P, Sicinski RR, Atigadda V, Jetten AM, Holick MF, Tuckey RC. Slominski AT, et al. Among authors: tang eky. FASEB J. 2022 Aug;36(8):e22451. doi: 10.1096/fj.202200578R. FASEB J. 2022. PMID: 35838947 Free PMC article.
Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs).
Slominski AT, Kim TK, Qayyum S, Song Y, Janjetovic Z, Oak ASW, Slominski RM, Raman C, Stefan J, Mier-Aguilar CA, Atigadda V, Crossman DK, Golub A, Bilokin Y, Tang EKY, Chen JY, Tuckey RC, Jetten AM, Song Y. Slominski AT, et al. Among authors: tang eky. Sci Rep. 2021 Apr 13;11(1):8002. doi: 10.1038/s41598-021-87061-w. Sci Rep. 2021. PMID: 33850196 Free PMC article.
Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms.
Chaiprasongsuk A, Janjetovic Z, Kim TK, Jarrett SG, D'Orazio JA, Holick MF, Tang EKY, Tuckey RC, Panich U, Li W, Slominski AT. Chaiprasongsuk A, et al. Among authors: tang eky. Redox Biol. 2019 Jun;24:101206. doi: 10.1016/j.redox.2019.101206. Epub 2019 Apr 20. Redox Biol. 2019. PMID: 31039479 Free PMC article.
37 results