Tan X - Search Results

1

Pharmacokinetics and Drug-Drug Interaction of Ocedurenone (KBP-5074) in vitro and in vivo.

Wang P, Liu J, Tan X, Yang F, McCabe J, Zhang J. Wang P, et al. Among authors: tan x. Eur J Drug Metab Pharmacokinet. 2023 Jul;48(4):397-410. doi: 10.1007/s13318-023-00837-5. Epub 2023 Jun 25. Eur J Drug Metab Pharmacokinet. 2023. PMID: 37357226 Free PMC article.

2

Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis.

Huang Z, Li H, Zhang Q, Tan X, Lu F, Liu H, Li S. Huang Z, et al. Among authors: tan x. Drug Des Devel Ther. 2015 Aug 5;9:4319-28. doi: 10.2147/DDDT.S83055. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26273193 Free PMC article.

3

In Vitro Activity of KBP-7072, a Novel Third-Generation Tetracycline, against 531 Recent Geographically Diverse and Molecularly Characterized Acinetobacter baumannii Species Complex Isolates.

Huband MD, Mendes RE, Pfaller MA, Lindley JM, Strand GJ, Benn VJ, Zhang J, Li L, Zhang M, Tan X, Liu Q, Flamm RK. Huband MD, et al. Among authors: tan x. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02375-19. doi: 10.1128/AAC.02375-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32071042 Free PMC article.

4

Nonclinical Pharmacokinetics, Protein Binding, and Elimination of KBP-7072, an Aminomethylcycline Antibiotic, in Animal Models.

Tan X, Zhang M, Liu Q, Wang P, Zhou T, Zhu Y, Chen B, Wang M, Xia Y, Benn V, Yang F, Zhang J. Tan X, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e00488-20. doi: 10.1128/AAC.00488-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32229494 Free PMC article.

5

In vitro activity of KHP-3757 (a novel LpxC inhibitor) and comparator agents against recent and molecularly characterized Pseudomonas aeruginosa isolates from a global surveillance program (2017-2018).

Huband MD, Lindley JM, Mendes RE, Fedler KA, Benn VJ, Zhang J, Zhong G, Li L, Zhang M, Tan X, Flamm RK. Huband MD, et al. Among authors: tan x. Diagn Microbiol Infect Dis. 2020 Dec;98(4):115191. doi: 10.1016/j.diagmicrobio.2020.115191. Epub 2020 Aug 24. Diagn Microbiol Infect Dis. 2020. PMID: 32950854

6

The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury.

Jaisser F, Tan X, Chi S, Liu J, Wang P, Bush M, Benn V, Yang YF, Zhang J. Jaisser F, et al. Among authors: tan x. Front Pharmacol. 2021 Jun 24;12:604928. doi: 10.3389/fphar.2021.604928. eCollection 2021. Front Pharmacol. 2021. PMID: 34248613 Free PMC article.

7

In Vitro Activity of KBP-7072 against 536 Acinetobacter baumannii Complex Isolates Collected in China.

Han R, Ding L, Yang Y, Guo Y, Yin D, Wu S, Zhi P, Zhu D, Liu Q, Tan X, Zhu Y, Zhang J, Li L, Hu F. Han R, et al. Among authors: tan x. Microbiol Spectr. 2022 Feb 23;10(1):e0147121. doi: 10.1128/spectrum.01471-21. Epub 2022 Feb 9. Microbiol Spectr. 2022. PMID: 35138143 Free PMC article.

8

In vivo efficacy and PK/PD analyses of zifanocycline (KBP-7072), an aminomethylcycline antibiotic, against Acinetobacter baumannii in a neutropenic murine thigh infection model.

Li L, Tan X, Zhou T, Chi S, Zhu Y, Liu Q, Chen Y, Zhang J. Li L, et al. Among authors: tan x. J Infect Chemother. 2024 Jan;30(1):34-39. doi: 10.1016/j.jiac.2023.09.010. Epub 2023 Sep 14. J Infect Chemother. 2024. PMID: 37714267 Free article.

9

Approaching the active conformation of 1,3-diaminopyrimidine based covalent inhibitors of Bruton's tyrosine kinase for treatment of Rheumatoid arthritis.

Huang Z, Zhang Q, Yan L, Zhong G, Zhang L, Tan X, Wang Y. Huang Z, et al. Among authors: tan x. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1954-7. doi: 10.1016/j.bmcl.2016.03.011. Epub 2016 Mar 4. Bioorg Med Chem Lett. 2016. PMID: 26976214

10

The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development.

Zhang Z, Zhou L, Liu Q, Zheng Y, Tan X, Huang Z, Guo M, Wang X, Chen X, Liang S, Li W, Song K, Yan K, Li J, Li Q, Zhang Y, Yang S, Cai Z, Dai M, Xian Q, Shi ZL, Xu K, Lan K, Chen Y. Zhang Z, et al. Among authors: tan x. Emerg Microbes Infect. 2024 May 16:2353302. doi: 10.1080/22221751.2024.2353302. Online ahead of print. Emerg Microbes Infect. 2024. PMID: 38753462

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