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A trimethoprim derivative impedes antibiotic resistance evolution.
Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E. Manna MS, et al. Among authors: tambar u. Nat Commun. 2021 May 19;12(1):2949. doi: 10.1038/s41467-021-23191-z. Nat Commun. 2021. PMID: 34011959 Free PMC article.
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716694 Free PMC article.
Copper-Catalyzed Regiodivergent Internal Allylic Alkylations.
Manna MS, Yoo SY, Sharique M, Choi H, Pudasaini B, Baik MH, Tambar UK. Manna MS, et al. Among authors: tambar uk. Angew Chem Int Ed Engl. 2023 Aug 28;62(35):e202304848. doi: 10.1002/anie.202304848. Epub 2023 Jul 17. Angew Chem Int Ed Engl. 2023. PMID: 37327025
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Scheuermann TH, et al. Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24. Nat Chem Biol. 2013. PMID: 23434853 Free PMC article.
53 results