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Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells.
Malyukova A, Ujvari D, Yektaei-Karin E, Zovko A, Madapura HS, Keszei M, Nagy N, Lotfi K, Björn N, Wallvik J, Tamai M, Nguyen TTT, Akahane K, Inukai T, Stenke L, Salamon D. Malyukova A, et al. Among authors: tamai m. Cell Death Dis. 2021 Sep 25;12(10):875. doi: 10.1038/s41419-021-04154-0. Cell Death Dis. 2021. PMID: 34564697 Free PMC article.
Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia.
Kumar R, Pereira RS, Zanetti C, Minciacchi VR, Merten M, Meister M, Niemann J, Dietz MS, Rüssel N, Schnütgen F, Tamai M, Akahane K, Inukai T, Oellerich T, Kvasnicka HM, Pfeifer H, Nicolini FE, Heilemann M, Van Etten RA, Krause DS. Kumar R, et al. Among authors: tamai m. Leukemia. 2020 Aug;34(8):2087-2101. doi: 10.1038/s41375-020-0866-1. Epub 2020 May 21. Leukemia. 2020. PMID: 32439895 Free PMC article.
IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform.
Harama D, Yahata T, Kagami K, Abe M, Ando N, Kasai S, Tamai M, Akahane K, Inukai T, Kiyokawa N, Ibrahim AA, Ando K, Sugita K. Harama D, et al. Among authors: tamai m. Cell Death Discov. 2021 Jun 11;7(1):139. doi: 10.1038/s41420-021-00523-y. Cell Death Discov. 2021. PMID: 34117218 Free PMC article.
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
Somazu S, Tanaka Y, Tamai M, Watanabe A, Kagami K, Abe M, Harama D, Shinohara T, Akahane K, Goi K, Sugita K, Moriyama T, Yang J, Goto H, Minegishi M, Iwamoto S, Takita J, Inukai T. Somazu S, et al. Among authors: tamai m. J Cell Mol Med. 2021 Nov;25(22):10521-10533. doi: 10.1111/jcmm.16981. Epub 2021 Oct 12. J Cell Mol Med. 2021. PMID: 34636169 Free PMC article.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Tamai M, Kasai S, Akahane K, Thu TN, Kagami K, Komatsu C, Abe M, Watanabe A, Goi K, Miyake K, Inaba T, Takita J, Goto H, Minegishi M, Iwamoto S, Sugita K, Inukai T. Tamai M, et al. J Steroid Biochem Mol Biol. 2022 Apr;218:106068. doi: 10.1016/j.jsbmb.2022.106068. Epub 2022 Feb 4. J Steroid Biochem Mol Biol. 2022. PMID: 35124168 Free article.
899 results