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A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent.
Gioelli N, Maione F, Camillo C, Ghitti M, Valdembri D, Morello N, Darche M, Zentilin L, Cagnoni G, Qiu Y, Giacca M, Giustetto M, Paques M, Cascone I, Musco G, Tamagnone L, Giraudo E, Serini G. Gioelli N, et al. Among authors: tamagnone l. Sci Transl Med. 2018 May 23;10(442):eaah4807. doi: 10.1126/scitranslmed.aah4807. Sci Transl Med. 2018. PMID: 29794061 Free article.
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.
Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F, Zammataro L, Primo L, Tamagnone L, Logan M, Tessier-Lavigne M, Taniguchi M, Püschel AW, Bussolino F. Serini G, et al. Among authors: tamagnone l. Nature. 2003 Jul 24;424(6947):391-7. doi: 10.1038/nature01784. Nature. 2003. PMID: 12879061
Sema4D induces angiogenesis through Met recruitment by Plexin B1.
Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S. Conrotto P, et al. Among authors: tamagnone l. Blood. 2005 Jun 1;105(11):4321-9. doi: 10.1182/blood-2004-07-2885. Epub 2005 Jan 4. Blood. 2005. PMID: 15632204 Free article.
Neuropilin-1-dependent regulation of EGF-receptor signaling.
Rizzolio S, Rabinowicz N, Rainero E, Lanzetti L, Serini G, Norman J, Neufeld G, Tamagnone L. Rizzolio S, et al. Among authors: tamagnone l. Cancer Res. 2012 Nov 15;72(22):5801-11. doi: 10.1158/0008-5472.CAN-12-0995. Epub 2012 Sep 17. Cancer Res. 2012. PMID: 22986738 Free article.
Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Giacobini P, et al. Among authors: tamagnone l. PLoS Biol. 2014 Mar 11;12(3):e1001808. doi: 10.1371/journal.pbio.1001808. eCollection 2014 Mar. PLoS Biol. 2014. PMID: 24618750 Free PMC article.
Bad vessels beware! Semaphorins will sort you out!
Serini G, Tamagnone L. Serini G, et al. Among authors: tamagnone l. EMBO Mol Med. 2015 Oct;7(10):1251-3. doi: 10.15252/emmm.201505551. EMBO Mol Med. 2015. PMID: 26311294 Free PMC article.
130 results