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Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H. Inoue N, et al. Among authors: takeuchi y. J Biol Chem. 2008 Jul 25;283(30):21220-9. doi: 10.1074/jbc.M801824200. Epub 2008 Apr 29. J Biol Chem. 2008. PMID: 18445590 Free PMC article.
Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.
Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H. Izumida Y, et al. Among authors: takeuchi y. Nat Commun. 2013;4:2316. doi: 10.1038/ncomms3316. Nat Commun. 2013. PMID: 23939267 Free PMC article.
Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: takeuchi y. Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18. Endocrinology. 2014. PMID: 25233440
Identification of human ELOVL5 enhancer regions controlled by SREBP.
Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N. Shikama A, et al. Among authors: takeuchi y. Biochem Biophys Res Commun. 2015 Oct 2;465(4):857-63. doi: 10.1016/j.bbrc.2015.08.101. Epub 2015 Aug 28. Biochem Biophys Res Commun. 2015. PMID: 26321664
KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.
Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H. Takeuchi Y, et al. Cell Rep. 2016 Aug 30;16(9):2373-86. doi: 10.1016/j.celrep.2016.07.069. Epub 2016 Aug 18. Cell Rep. 2016. PMID: 27545894 Free PMC article.
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H. Kikuchi T, et al. Among authors: takeuchi y. Mol Metab. 2016 Sep 17;5(11):1092-1102. doi: 10.1016/j.molmet.2016.09.004. eCollection 2016 Nov. Mol Metab. 2016. PMID: 27818935 Free PMC article.
A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.
Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H. Nishi-Tatsumi M, et al. Among authors: takeuchi y. FEBS Lett. 2017 Apr;591(7):965-978. doi: 10.1002/1873-3468.12620. Epub 2017 Mar 27. FEBS Lett. 2017. PMID: 28281280 Free article.
Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.
Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H. Zhao H, et al. Among authors: takeuchi y. Diabetes. 2017 Jul;66(7):1833-1846. doi: 10.2337/db16-1277. Epub 2017 May 1. Diabetes. 2017. PMID: 28461456
4,024 results