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Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma.
Yasumizu Y, Ohkura N, Murata H, Kinoshita M, Funaki S, Nojima S, Kido K, Kohara M, Motooka D, Okuzaki D, Suganami S, Takeuchi E, Nakamura Y, Takeshima Y, Arai M, Tada S, Okumura M, Morii E, Shintani Y, Sakaguchi S, Okuno T, Mochizuki H. Yasumizu Y, et al. Among authors: takeshima y. Nat Commun. 2022 Jul 22;13(1):4230. doi: 10.1038/s41467-022-31951-8. Nat Commun. 2022. PMID: 35869073 Free PMC article.
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
Mimitou EP, Lareau CA, Chen KY, Zorzetto-Fernandes AL, Hao Y, Takeshima Y, Luo W, Huang TS, Yeung BZ, Papalexi E, Thakore PI, Kibayashi T, Wing JB, Hata M, Satija R, Nazor KL, Sakaguchi S, Ludwig LS, Sankaran VG, Regev A, Smibert P. Mimitou EP, et al. Among authors: takeshima y. Nat Biotechnol. 2021 Oct;39(10):1246-1258. doi: 10.1038/s41587-021-00927-2. Epub 2021 Jun 3. Nat Biotechnol. 2021. PMID: 34083792 Free PMC article.
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells.
Yamaguchi Y, Kato Y, Edahiro R, Søndergaard JN, Murakami T, Amiya S, Nameki S, Yoshimine Y, Morita T, Takeshima Y, Sakakibara S, Naito Y, Motooka D, Liu YC, Shirai Y, Okita Y, Fujimoto J, Hirata H, Takeda Y, Wing JB, Okuzaki D, Okada Y, Kumanogoh A. Yamaguchi Y, et al. Among authors: takeshima y. JCI Insight. 2022 Nov 22;7(22):e163347. doi: 10.1172/jci.insight.163347. JCI Insight. 2022. PMID: 36282593 Free PMC article.
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.
Edahiro R, Shirai Y, Takeshima Y, Sakakibara S, Yamaguchi Y, Murakami T, Morita T, Kato Y, Liu YC, Motooka D, Naito Y, Takuwa A, Sugihara F, Tanaka K, Wing JB, Sonehara K, Tomofuji Y; Japan COVID-19 Task Force; Namkoong H, Tanaka H, Lee H, Fukunaga K, Hirata H, Takeda Y, Okuzaki D, Kumanogoh A, Okada Y. Edahiro R, et al. Among authors: takeshima y. Nat Genet. 2023 May;55(5):753-767. doi: 10.1038/s41588-023-01375-1. Epub 2023 Apr 24. Nat Genet. 2023. PMID: 37095364 Free PMC article.
Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases.
Yasumizu Y, Takeuchi D, Morimoto R, Takeshima Y, Okuno T, Kinoshita M, Morita T, Kato Y, Wang M, Motooka D, Okuzaki D, Nakamura Y, Mikami N, Arai M, Zhang X, Kumanogoh A, Mochizuki H, Ohkura N, Sakaguchi S. Yasumizu Y, et al. Among authors: takeshima y. Cell Genom. 2024 Feb 14;4(2):100473. doi: 10.1016/j.xgen.2023.100473. Epub 2024 Jan 3. Cell Genom. 2024. PMID: 38359792 Free PMC article.
Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.
Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, Takeshima Y, Yanaoka H, Kobayashi S, Okubo M, Shirai H, Sugimori Y, Maeda J, Nakano M, Yamada S, Yoshida R, Tsuchiya H, Tsuchida Y, Akizuki S, Yoshifuji H, Ohmura K, Mimori T, Yoshida K, Kurosaka D, Okada M, Setoguchi K, Kaneko H, Ban N, Yabuki N, Matsuki K, Mutoh H, Oyama S, Okazaki M, Tsunoda H, Iwasaki Y, Sumitomo S, Shoda H, Kochi Y, Okada Y, Yamamoto K, Okamura T, Fujio K. Ota M, et al. Among authors: takeshima y. Cell. 2021 May 27;184(11):3006-3021.e17. doi: 10.1016/j.cell.2021.03.056. Epub 2021 May 1. Cell. 2021. PMID: 33930287 Free article.
Transcriptome analysis of immune cells from Behçet's syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet's syndrome.
Okubo M, Sumitomo S, Tsuchida Y, Nagafuchi Y, Takeshima Y, Yanaoka H, Shirai H, Kobayashi S, Sugimori Y, Maeda J, Hatano H, Iwasaki Y, Shoda H, Okamura T, Yamamoto K, Ota M, Fujio K. Okubo M, et al. Among authors: takeshima y. Arthritis Res Ther. 2022 Aug 8;24(1):186. doi: 10.1186/s13075-022-02867-x. Arthritis Res Ther. 2022. PMID: 35941595 Free PMC article.
Polymorphic lymphoproliferative disorders in patients with rheumatoid arthritis are associated with a better clinical outcome.
Tsukui D, Kanda H, Shinozaki-Ushiku A, Tateishi S, Takeshima Y, Nagafuchi Y, Sasaki O, Iwasaki Y, Harada H, Shibuya M, Sumitomo S, Shoda H, Kubo K, Fujio K, Nakamura F, Kurokawa M, Fukayama M, Yamamoto K. Tsukui D, et al. Among authors: takeshima y. Mod Rheumatol. 2018 Jul;28(4):621-625. doi: 10.1080/14397595.2017.1387223. Epub 2017 Oct 23. Mod Rheumatol. 2018. PMID: 29057700
628 results