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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop.
Hua Y, Vella G, Rambow F, Allen E, Antoranz Martinez A, Duhamel M, Takeda A, Jalkanen S, Junius S, Smeets A, Nittner D, Dimmeler S, Hehlgans T, Liston A, Bosisio FM, Floris G, Laoui D, Hollmén M, Lambrechts D, Merchiers P, Marine JC, Schlenner S, Bergers G. Hua Y, et al. Among authors: takeda a. Cancer Cell. 2022 Dec 12;40(12):1600-1618.e10. doi: 10.1016/j.ccell.2022.11.002. Epub 2022 Nov 23. Cancer Cell. 2022. PMID: 36423635 Free PMC article.
Single-Cell Transcriptomics of Human Lymph Node Stroma.
Takeda A, Jalkanen S. Takeda A, et al. STAR Protoc. 2020 Jun 3;1(1):100021. doi: 10.1016/j.xpro.2020.100021. eCollection 2020 Jun 19. STAR Protoc. 2020. PMID: 33111075 Free PMC article.
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial.
Virtakoivu R, Rannikko JH, Viitala M, Vaura F, Takeda A, Lönnberg T, Koivunen J, Jaakkola P, Pasanen A, Shetty S, de Jonge MJA, Robbrecht D, Ma YT, Skyttä T, Minchom A, Jalkanen S, Karvonen MK, Mandelin J, Bono P, Hollmén M. Virtakoivu R, et al. Among authors: takeda a. Clin Cancer Res. 2021 Aug 1;27(15):4205-4220. doi: 10.1158/1078-0432.CCR-20-4862. Epub 2021 Jun 2. Clin Cancer Res. 2021. PMID: 34078651 Free PMC article. Clinical Trial.
Clever-1 contributes to lymphocyte entry into the spleen via the red pulp.
Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S. Tadayon S, et al. Among authors: takeda a. Sci Immunol. 2019 Mar 29;4(33):eaat0297. doi: 10.1126/sciimmunol.aat0297. Sci Immunol. 2019. PMID: 30926591
2,130 results