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Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Bioorg Med Chem. 2024 Jan 15;98:117561. doi: 10.1016/j.bmc.2023.117561. Epub 2023 Dec 20.
Bioorg Med Chem. 2024.
PMID: 38157838
Free article.
A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells.
Cunha MR, Catta-Preta CMC, Takarada JE, Moreira GA, Massirer KB, Couñago RM.
Cunha MR, et al. Among authors: takarada je.
J Biol Chem. 2023 Jun;299(6):104807. doi: 10.1016/j.jbc.2023.104807. Epub 2023 May 11.
J Biol Chem. 2023.
PMID: 37172730
Free PMC article.
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Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Segretti ND, Takarada JE, Ferreira MA Jr, da Silva Santiago A, Teodoro BVM, Damião MCFCB, Godoi PH, Cunha MR, Fala AM, Ramos PZ, Ishikawa EE, Mascarello A, Serafim RAM, Azevedo H, Guimarães CRW, Couñago RM.
Segretti ND, et al. Among authors: takarada je.
Bioorg Med Chem Lett. 2022 Jul 15;68:128764. doi: 10.1016/j.bmcl.2022.128764. Epub 2022 May 2.
Bioorg Med Chem Lett. 2022.
PMID: 35504513
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Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
M Serafim RA, da Silva Santiago A, Schwalm MP, Hu Z, Dos Reis CV, Takarada JE, Mezzomo P, Massirer KB, Kudolo M, Gerstenecker S, Chaikuad A, Zender L, Knapp S, Laufer S, Couñago RM, Gehringer M.
M Serafim RA, et al. Among authors: takarada je.
J Med Chem. 2022 Feb 24;65(4):3173-3192. doi: 10.1021/acs.jmedchem.1c01165. Epub 2022 Feb 15.
J Med Chem. 2022.
PMID: 35167750
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Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Scott F, Fala AM, Takarada JE, Ficu MP, Pennicott LE, Reuillon TD, Couñago RM, Massirer KB, Elkins JM, Ward SE.
Scott F, et al. Among authors: takarada je.
Bioorg Med Chem Lett. 2022 Mar 15;60:128588. doi: 10.1016/j.bmcl.2022.128588. Epub 2022 Jan 29.
Bioorg Med Chem Lett. 2022.
PMID: 35104640
Free article.
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Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding.
da Silva MM , de Camargo MS , Correa RS , Castelli S , De Grandis RA , Takarada JE , Varanda EA , Castellano EE , Deflon VM , Cominetti MR , Desideri A , Batista AA .
da Silva MM , et al. Among authors: takarada je.
Dalton Trans. 2019 Oct 7;48(39):14885-14897. doi: 10.1039/c9dt01905g.
Dalton Trans. 2019.
PMID: 31555783
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Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM.
Serafim RAM, et al. Among authors: takarada je.
ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12.
ACS Med Chem Lett. 2019.
PMID: 31531195
Free PMC article.
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Ru/Fe bimetallic complexes: Synthesis, characterization, cytotoxicity and study of their interactions with DNA/HSA and human topoisomerase IB.
Takarada JE, Guedes APM, Correa RS, Silveira-Lacerda EP, Castelli S, Iacovelli F, Deflon VM, Batista AA, Desideri A.
Takarada JE, et al.
Arch Biochem Biophys. 2017 Dec 15;636:28-41. doi: 10.1016/j.abb.2017.10.015. Epub 2017 Oct 28.
Arch Biochem Biophys. 2017.
PMID: 29107586
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