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Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H. Takeshita H, et al. Among authors: takahashi t. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):975-986. doi: 10.1002/jcsm.12334. Epub 2018 Sep 11. J Cachexia Sarcopenia Muscle. 2018. PMID: 30207087 Free PMC article.
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle.
Fujimoto T, Sugimoto K, Takahashi T, Yasunobe Y, Xie K, Tanaka M, Ohnishi Y, Yoshida S, Kurinami H, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Rakugi H. Fujimoto T, et al. Among authors: takahashi t. Biochem Biophys Res Commun. 2019 Feb 19;509(4):994-1000. doi: 10.1016/j.bbrc.2019.01.024. Epub 2019 Jan 14. Biochem Biophys Res Commun. 2019. PMID: 30654941
Preventive effects of low-intensity exercise on cancer cachexia-induced muscle atrophy.
Tanaka M, Sugimoto K, Fujimoto T, Xie K, Takahashi T, Akasaka H, Kurinami H, Yasunobe Y, Matsumoto T, Fujino H, Rakugi H. Tanaka M, et al. Among authors: takahashi t. FASEB J. 2019 Jul;33(7):7852-7862. doi: 10.1096/fj.201802430R. Epub 2019 Mar 27. FASEB J. 2019. PMID: 30916585
These results suggest that low-intensity exercise has the potential to become an effective therapeutic intervention for the prevention of cancer cachexia-induced muscle atrophy.-Tanaka, M., Sugimoto, K., Fujimoto, T., Xie, K., Takahashi, T., Akasaka, H., Kuri …
These results suggest that low-intensity exercise has the potential to become an effective therapeutic intervention for the prevention of ca …
Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis.
Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. Piplani H, et al. Among authors: takahashi t. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165530. doi: 10.1016/j.bbadis.2019.08.006. Epub 2019 Aug 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31398467 Free article.
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, Roche PA, Cattral MS, Gaisano HY. Dolai S, et al. Among authors: takahashi t. Autophagy. 2021 Oct;17(10):3068-3081. doi: 10.1080/15548627.2020.1852725. Epub 2020 Dec 7. Autophagy. 2021. PMID: 33213278 Free PMC article.
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor.
Takahashi T, Huang Y, Yamamoto K, Hamano G, Kakino A, Kang F, Imaizumi Y, Takeshita H, Nozato Y, Nozato S, Yokoyama S, Nagasawa M, Kawai T, Takeda M, Fujimoto T, Hongyo K, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Gaisano HY, Sawamura T, Rakugi H. Takahashi T, et al. iScience. 2021 Jan 21;24(2):102076. doi: 10.1016/j.isci.2021.102076. eCollection 2021 Feb 19. iScience. 2021. PMID: 33659870 Free PMC article.
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Yokoyama S, Kawai T, Yamamoto K, Yibin H, Yamamoto H, Kakino A, Takeshita H, Nozato Y, Fujimoto T, Hongyo K, Takahashi T, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Sawamura T, Rakugi H. Yokoyama S, et al. Among authors: takahashi t. Sci Rep. 2021 Mar 11;11(1):5759. doi: 10.1038/s41598-021-85312-4. Sci Rep. 2021. PMID: 33707701 Free PMC article.
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