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Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis.
Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. Piplani H, et al. Among authors: takahashi t. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165530. doi: 10.1016/j.bbadis.2019.08.006. Epub 2019 Aug 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31398467 Free article.
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, Roche PA, Cattral MS, Gaisano HY. Dolai S, et al. Among authors: takahashi t. Autophagy. 2021 Oct;17(10):3068-3081. doi: 10.1080/15548627.2020.1852725. Epub 2020 Dec 7. Autophagy. 2021. PMID: 33213278 Free PMC article.
Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis.
Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z Jr, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. Mareninova OA, et al. Among authors: takahashi t. J Clin Invest. 2021 Aug 2;131(15):e146870. doi: 10.1172/JCI146870. J Clin Invest. 2021. PMID: 34128834 Free PMC article.
Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS. Mareninova OA, et al. Among authors: takahashi t. Cell Mol Gastroenterol Hepatol. 2022;13(2):599-622. doi: 10.1016/j.jcmgh.2021.09.017. Epub 2021 Oct 2. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34610499 Free PMC article.
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor.
Takahashi T, Huang Y, Yamamoto K, Hamano G, Kakino A, Kang F, Imaizumi Y, Takeshita H, Nozato Y, Nozato S, Yokoyama S, Nagasawa M, Kawai T, Takeda M, Fujimoto T, Hongyo K, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Gaisano HY, Sawamura T, Rakugi H. Takahashi T, et al. iScience. 2021 Jan 21;24(2):102076. doi: 10.1016/j.isci.2021.102076. eCollection 2021 Feb 19. iScience. 2021. PMID: 33659870 Free PMC article.
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle.
Fujimoto T, Sugimoto K, Takahashi T, Yasunobe Y, Xie K, Tanaka M, Ohnishi Y, Yoshida S, Kurinami H, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Rakugi H. Fujimoto T, et al. Among authors: takahashi t. Biochem Biophys Res Commun. 2019 Feb 19;509(4):994-1000. doi: 10.1016/j.bbrc.2019.01.024. Epub 2019 Jan 14. Biochem Biophys Res Commun. 2019. PMID: 30654941
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