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Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat.
Hayami T, Yokoi N, Yamaguchi T, Honda K, Murao N, Takahashi H, Wang S, Seino Y, Kamiya H, Yabe D, Sweet IR, Mizoguchi A, Nakamura J, Seino S. Hayami T, et al. Among authors: takahashi h. J Diabetes Investig. 2020 Nov;11(6):1434-1447. doi: 10.1111/jdi.13272. Epub 2020 May 29. J Diabetes Investig. 2020. PMID: 32279428 Free PMC article.
Glutamate is an essential mediator in glutamine-amplified insulin secretion.
Han G, Takahashi H, Murao N, Gheni G, Yokoi N, Hamamoto Y, Asahara SI, Seino Y, Kido Y, Seino S. Han G, et al. Among authors: takahashi h. J Diabetes Investig. 2021 Jun;12(6):920-930. doi: 10.1111/jdi.13497. Epub 2021 Feb 17. J Diabetes Investig. 2021. PMID: 33417747 Free PMC article.
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S. Gheni G, et al. Among authors: takahashi h. Cell Rep. 2014 Oct 23;9(2):661-73. doi: 10.1016/j.celrep.2014.09.030. Epub 2014 Oct 16. Cell Rep. 2014. PMID: 25373904 Free PMC article.
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