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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.
Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S. Shibasaki T, et al. Among authors: takahashi h. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19333-8. doi: 10.1073/pnas.0707054104. Epub 2007 Nov 26. Proc Natl Acad Sci U S A. 2007. PMID: 18040047 Free PMC article.
Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.
Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S. Takahashi T, et al. Among authors: takahashi h. Sci Signal. 2013 Oct 22;6(298):ra94. doi: 10.1126/scisignal.2004581. Sci Signal. 2013. PMID: 24150255
Structure and functional roles of Epac2 (Rapgef4).
Sugawara K, Shibasaki T, Takahashi H, Seino S. Sugawara K, et al. Among authors: takahashi h. Gene. 2016 Jan 10;575(2 Pt 3):577-83. doi: 10.1016/j.gene.2015.09.029. Epub 2015 Sep 24. Gene. 2016. PMID: 26390815 Free PMC article. Review.
Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat.
Hayami T, Yokoi N, Yamaguchi T, Honda K, Murao N, Takahashi H, Wang S, Seino Y, Kamiya H, Yabe D, Sweet IR, Mizoguchi A, Nakamura J, Seino S. Hayami T, et al. Among authors: takahashi h. J Diabetes Investig. 2020 Nov;11(6):1434-1447. doi: 10.1111/jdi.13272. Epub 2020 May 29. J Diabetes Investig. 2020. PMID: 32279428 Free PMC article.
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