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Page 1
Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.
Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, Suzuki-Kemuriyama N, Kuba M, Okajima Y, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Takahashi A, Suzuki H, Sone H, Shimada M, Nakagawa Y, Yahagi N, Yamada N, Shimano H. Tang N, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2014 Jul 18;450(1):318-23. doi: 10.1016/j.bbrc.2014.05.113. Epub 2014 Jun 2. Biochem Biophys Res Commun. 2014. PMID: 24938128
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N. Matsuzaka T, et al. Among authors: takahashi a. Nat Med. 2007 Oct;13(10):1193-202. doi: 10.1038/nm1662. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906635
Mouse Elovl-6 promoter is an SREBP target.
Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H. Kumadaki S, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2008 Apr 4;368(2):261-6. doi: 10.1016/j.bbrc.2008.01.075. Epub 2008 Jan 28. Biochem Biophys Res Commun. 2008. PMID: 18226595
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N. Kato T, et al. Among authors: takahashi a. Diabetes. 2008 Sep;57(9):2382-92. doi: 10.2337/db06-1806. Epub 2008 May 5. Diabetes. 2008. PMID: 18458149 Free PMC article.
Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.
Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Suzuki H, Yamada N, Shimano H. Iwasaki Y, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2009 Jan 16;378(3):545-50. doi: 10.1016/j.bbrc.2008.11.105. Epub 2008 Dec 3. Biochem Biophys Res Commun. 2009. PMID: 19056350
The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.
Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, Yahagi N, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Urayama O, Yamada N, Shimano H. Nakanishi N, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2009 Aug 7;385(4):492-6. doi: 10.1016/j.bbrc.2009.05.058. Epub 2009 May 19. Biochem Biophys Res Commun. 2009. PMID: 19460359
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.
Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H. Danno H, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1222-7. doi: 10.1016/j.bbrc.2009.12.046. Epub 2009 Dec 16. Biochem Biophys Res Commun. 2010. PMID: 20006574
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Saito R, et al. Among authors: takahashi a. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. doi: 10.1161/ATVBAHA.110.221663. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817094
Elovl6 promotes nonalcoholic steatohepatitis.
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H. Matsuzaka T, et al. Among authors: takahashi a. Hepatology. 2012 Dec;56(6):2199-208. doi: 10.1002/hep.25932. Hepatology. 2012. PMID: 22753171
Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.
Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H. Osaki Y, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14. Biochem Biophys Res Commun. 2015. PMID: 26381177
4,824 results