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An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. Urano E, et al. Among authors: takagi j. Sci Transl Med. 2023 Aug 30;15(711):eadi2623. doi: 10.1126/scitranslmed.adi2623. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647387
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo.
Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A. Ikemura N, et al. Among authors: takagi j. Sci Transl Med. 2022 Jun 22;14(650):eabn7737. doi: 10.1126/scitranslmed.abn7737. Epub 2022 Jun 22. Sci Transl Med. 2022. PMID: 35471044 Free PMC article.
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.
Higuchi Y, Suzuki T, Arimori T, Ikemura N, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T, Takagi J, Hoshino A. Higuchi Y, et al. Among authors: takagi j. Nat Commun. 2021 Jun 21;12(1):3802. doi: 10.1038/s41467-021-24013-y. Nat Commun. 2021. PMID: 34155214 Free PMC article.
Engineering ACE2 decoy receptors to combat viral escapability.
Arimori T, Ikemura N, Okamoto T, Takagi J, Standley DM, Hoshino A. Arimori T, et al. Among authors: takagi j. Trends Pharmacol Sci. 2022 Oct;43(10):838-851. doi: 10.1016/j.tips.2022.06.011. Epub 2022 Jul 25. Trends Pharmacol Sci. 2022. PMID: 35902282 Free PMC article. Review.
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.
Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H. Saito F, et al. Among authors: takagi j. Nature. 2017 Dec 7;552(7683):101-105. doi: 10.1038/nature24994. Epub 2017 Nov 29. Nature. 2017. PMID: 29186116 Free PMC article.
De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function.
Sugano-Nakamura N, Matoba K, Hirose M, Bashiruddin NK, Matsunaga Y, Yamashita K, Hirata K, Yamamoto M, Arimori T, Suga H, Takagi J. Sugano-Nakamura N, et al. Among authors: takagi j. Structure. 2022 Oct 6;30(10):1411-1423.e4. doi: 10.1016/j.str.2022.07.008. Epub 2022 Aug 17. Structure. 2022. PMID: 35981535 Free article.
Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N. Hasegawa K, et al. Among authors: takagi j. Sci Transl Med. 2022 Feb 16;14(632):eaax7706. doi: 10.1126/scitranslmed.aax7706. Epub 2022 Feb 16. Sci Transl Med. 2022. PMID: 35171652
347 results