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Proteome-scale discovery of protein degradation and stabilization effectors.
Poirson J, Cho H, Dhillon A, Haider S, Imrit AZ, Lam MHY, Alerasool N, Lacoste J, Mizan L, Wong C, Gingras AC, Schramek D, Taipale M. Poirson J, et al. Among authors: taipale m. Nature. 2024 Apr;628(8009):878-886. doi: 10.1038/s41586-024-07224-3. Epub 2024 Mar 20. Nature. 2024. PMID: 38509365
Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription.
Downes N, Niskanen H, Tomas Bosch V, Taipale M, Godiwala M, Väänänen MA, Turunen TA, Aavik E, Laham-Karam N, Ylä-Herttuala S, Kaikkonen MU. Downes N, et al. Among authors: taipale m. J Biol Chem. 2023 Nov;299(11):105291. doi: 10.1016/j.jbc.2023.105291. Epub 2023 Sep 23. J Biol Chem. 2023. PMID: 37748649 Free PMC article.
Pervasive mislocalization of pathogenic coding variants underlying human disorders.
Lacoste J, Haghighi M, Haider S, Lin ZY, Segal D, Reno C, Qian WW, Xiong X, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Roth FP, Calderwood M, Hill D, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M. Lacoste J, et al. Among authors: taipale m. bioRxiv [Preprint]. 2023 Sep 5:2023.09.05.556368. doi: 10.1101/2023.09.05.556368. bioRxiv. 2023. PMID: 37732209 Free PMC article. Preprint.
PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells.
Denisova OV, Merisaari J, Huhtaniemi R, Qiao X, Yetukuri L, Jumppanen M, Kaur A, Pääkkönen M, von Schantz-Fant С, Ohlmeyer M, Wennerberg K, Kauko O, Koch R, Aittokallio T, Taipale M, Westermarck J. Denisova OV, et al. Among authors: taipale m. Mol Oncol. 2023 Sep;17(9):1803-1820. doi: 10.1002/1878-0261.13488. Epub 2023 Jul 26. Mol Oncol. 2023. PMID: 37458534 Free PMC article.
A central chaperone-like role for 14-3-3 proteins in human cells.
Segal D, Maier S, Mastromarco GJ, Qian WW, Nabeel-Shah S, Lee H, Moore G, Lacoste J, Larsen B, Lin ZY, Selvabaskaran A, Liu K, Smibert C, Zhang Z, Greenblatt J, Peng J, Lee HO, Gingras AC, Taipale M. Segal D, et al. Among authors: taipale m. Mol Cell. 2023 Mar 16;83(6):974-993.e15. doi: 10.1016/j.molcel.2023.02.018. Mol Cell. 2023. PMID: 36931259 Free article.
Simultaneous sequencing of genetic and epigenetic bases in DNA.
Füllgrabe J, Gosal WS, Creed P, Liu S, Lumby CK, Morley DJ, Ost TWB, Vilella AJ, Yu S, Bignell H, Burns P, Charlesworth T, Fu B, Fordham H, Harding NJ, Gandelman O, Golder P, Hodson C, Li M, Lila M, Liu Y, Mason J, Mellad J, Monahan JM, Nentwich O, Palmer A, Steward M, Taipale M, Vandomme A, San-Bento RS, Singhal A, Vivian J, Wójtowicz N, Williams N, Walker NJ, Wong NCH, Yalloway GN, Holbrook JD, Balasubramanian S. Füllgrabe J, et al. Among authors: taipale m. Nat Biotechnol. 2023 Oct;41(10):1457-1464. doi: 10.1038/s41587-022-01652-0. Epub 2023 Feb 6. Nat Biotechnol. 2023. PMID: 36747096 Free PMC article.
A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: taipale m. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
100 results