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Page 1
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Alsamman S, et al. Among authors: tager am. Sci Transl Med. 2020 Aug 19;12(557):eaay8798. doi: 10.1126/scitranslmed.aay8798. Sci Transl Med. 2020. PMID: 32817366 Free PMC article.
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: tager am. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.
Nakagawa S, Wei L, Song WM, Higashi T, Ghoshal S, Kim RS, Bian CB, Yamada S, Sun X, Venkatesh A, Goossens N, Bain G, Lauwers GY, Koh AP, El-Abtah M, Ahmad NB, Hoshida H, Erstad DJ, Gunasekaran G, Lee Y, Yu ML, Chuang WL, Dai CY, Kobayashi M, Kumada H, Beppu T, Baba H, Mahajan M, Nair VD, Lanuti M, Villanueva A, Sangiovanni A, Iavarone M, Colombo M, Llovet JM, Subramanian A, Tager AM, Friedman SL, Baumert TF, Schwarz ME, Chung RT, Tanabe KK, Zhang B, Fuchs BC, Hoshida Y; Precision Liver Cancer Prevention Consortium. Nakagawa S, et al. Among authors: tager am. Cancer Cell. 2016 Dec 12;30(6):879-890. doi: 10.1016/j.ccell.2016.11.004. Cancer Cell. 2016. PMID: 27960085 Free PMC article.
Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis.
Chen HH, Waghorn PA, Wei L, Tapias LF, Schühle DT, Rotile NJ, Jones CM, Looby RJ, Zhao G, Elliott JM, Probst CK, Mino-Kenudson M, Lauwers GY, Tager AM, Tanabe KK, Lanuti M, Fuchs BC, Caravan P. Chen HH, et al. Among authors: tager am. JCI Insight. 2017 Jun 2;2(11):e91506. doi: 10.1172/jci.insight.91506. eCollection 2017 Jun 2. JCI Insight. 2017. PMID: 28570270 Free PMC article.
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM. Lagares D, et al. Among authors: tager am. Sci Transl Med. 2017 Dec 13;9(420):eaal3765. doi: 10.1126/scitranslmed.aal3765. Sci Transl Med. 2017. PMID: 29237758 Free PMC article.
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis.
Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Haak AJ, et al. Among authors: tager am. Sci Transl Med. 2019 Oct 30;11(516):eaau6296. doi: 10.1126/scitranslmed.aau6296. Sci Transl Med. 2019. PMID: 31666402 Free PMC article.
Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Santos DM, Pantano L, Pronzati G, Grasberger P, Probst CK, Black KE, Spinney JJ, Hariri LP, Nichols R, Lin Y, Bieler M, Seither P, Nicklin P, Wyatt D, Tager AM, Medoff BD. Santos DM, et al. Among authors: tager am. Am J Respir Cell Mol Biol. 2020 Apr;62(4):479-492. doi: 10.1165/rcmb.2019-0296OC. Am J Respir Cell Mol Biol. 2020. PMID: 31944822 Free PMC article.
Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis.
Yang Y, Santos DM, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black KE, Spinney JJ, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager AM, Seither P, Herrmann FE, Medoff BD. Yang Y, et al. Among authors: tager am. Am J Respir Cell Mol Biol. 2022 Jul;67(1):36-49. doi: 10.1165/rcmb.2021-0428OC. Am J Respir Cell Mol Biol. 2022. PMID: 35377835 Free PMC article.
124 results