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Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured.
Suzuki T, Kawamura K, Li Q, Okamoto S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M. Suzuki T, et al. Among authors: tagawa m. BMC Cancer. 2014 Sep 25;14:713. doi: 10.1186/1471-2407-14-713. BMC Cancer. 2014. PMID: 25255777 Free PMC article.
Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma.
Yamauchi S, Kawamura K, Okamoto S, Morinaga T, Jiang Y, Shingyoji M, Sekine I, Kubo S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M. Yamauchi S, et al. Among authors: tagawa m. Apoptosis. 2015 Dec;20(12):1587-98. doi: 10.1007/s10495-015-1171-8. Apoptosis. 2015. PMID: 26373551
Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity.
Chai K, Ning X, Nguyễn TTT, Zhong B, Morinaga T, Li Z, Shingyoji M, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M. Chai K, et al. Among authors: tagawa m. Oncotarget. 2018 May 25;9(40):26130-26143. doi: 10.18632/oncotarget.25452. eCollection 2018 May 25. Oncotarget. 2018. PMID: 29899847 Free PMC article.
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